Shape a new future with innovation management standards

Innovation isn’t just having a few bright ideas. It’s about creating value and helping organizations continuously adapt and evolve. ISO is developing a new series of International Standards on innovation management, the third of which has just been published.

Innovation is an increasingly important contributor to the success of an organization, enhancing its ability to adapt in a changing world. Novel and innovative ideas give rise to better ways of working, as well as new solutions for generating revenue and improving sustainability. It is closely linked to the resilience of an organization, in that it helps them to understand and respond to challenging contexts, seize the opportunities that that might bring and leverage the creativity of both its own people and those it deals with.

Ultimately, big ideas and new inventions are often the result of a long series of little thoughts and changes, all captured and directed in the most effective way. One of the most efficient ways of doing just that is through implementing an innovation management system.

An innovation management system provides a systemic approach to integrate innovation into all the layers of the organizations in order to seize and create opportunities for the development of new solutions, systems, products and services. The first International Standard for such systems has just been published.

ISO 56002, Innovation management — Innovation management system — Guidance, covers all aspects of innovation management, from how to generate those first sparks of an idea, right through to selling something new in the marketplace. It considers the context that an organization is working in, the culture, strategy, processes and impact. It crosses many types of activities including products and services, business models, organizational innovation and more, and is applicable to all types of organization, regardless of size or type.

Alice de Casanove, Chair of the ISO technical committee who developed the standard says ISO 56002 will help organizations increase business opportunities and their performance in a multitude of ways:

“Every organization that wants to master their future needs to incorporate some aspects of innovation management. That is, they need to evolve and adapt to keep up with market and societal trends,” she says.

“The challenge is to identify what will give them the competitive edge and create value for the future, and thus which strategic actions to take. By providing guidance on how to best capture their ideas, test them effectively and manage the risks and opportunities associated, ISO 56002 can help organizations create new value propositions and maximize their potential in a structured way.”

ISO 56002 can also help to instill a culture of innovation in an organization, adds de Casanove, thereby harnessing the creativity and motivation of every member of the organization and ultimately improving the company’s collaboration, communication and performance.

ISO 56002 complements two other documents in the series that were recently published, ISO 56003, Innovation management — Tools and methods for innovation partnership — Guidance and ISO/TR 56004, Innovation Management Assessment — Guidance.

Future additions to the series include:

  • ISO 56000, Innovation management — Fundamentals and vocabulary
  • ISO 56005, Innovation management — Tools and methods for intellectual property management — Guidance
  • ISO 56006, Innovation management — Strategic intelligence management — Guidance
  • ISO 56007, Innovation management — Idea management

The technical committee has also been working closely with the Organization for Economic Co-operation and Development (OECD), the World Intellectual Property Organization (WIPO), the World Trade Organization (WTO) and the World Bank in developing this series.

ISO 56002 was developed by ISO/TC 279Innovation management, whose secretariat is held by AFNOR, ISO’s member for France. All the standards in the series can be purchased from your national ISO member or through the ISO Store

Related information

Contact

By |2019-07-16T11:55:18+00:00July 16th, 2019|Weld Engineering Services|Comments Off on Shape a new future with innovation management standards

New ISO standard for urban resilience in development

Urbanization is increasing, placing pressure on resources and infrastructure like never before. There’s no stemming the tide, so city leaders need to build resilience in order to cope. Work on a new International Standard for urban resilience, led by the United Nations, has just kicked off, aiming to help local governments build safer and more sustainable urban environments.

City living is where it’s at. The top 600 cities in the world house 20 % of the global population but produce 60 % of the world’s GDP, and the numbers are growing. It is estimated that, by 2050, 68 % of us will be living in cities1), increasing the scale of impact when disasters strike. Which they will. In 2018, for example, more than 17 million were displaced by sudden-onset disasters such as floods2). With climate change making such disasters more frequent and less predictable, urban areas need to be prepared.

Work has now started on a new ISO standard for urban resilience, aimed at supporting national and local governments build their capacity to face the new challenges arising from climate change and shifting demographics. It will define a framework for urban resilience, clarify the principles and concepts, and help users to identify, implement and monitor appropriate actions to make their cities more resilient.

The development of the standard is being led by UN-Habitat, the United Nations programme for human settlements, as part of their urban resilience programme. It will benefit from their 15 years of experience in the field, as well as that of international experts on the ISO technical committee responsible for the standard, ISO/TC 292, Security and resilience.

Esteban Leon, Head of the City Resilience Profiling Programme at UN-Habitat, and a key member of the working group developing the standard, highlighted that a resilient city must assess, plan and act to prepare for and respond to all challenges, whether they be sudden or not.

“This is a tall order and most cities need clearer guidance on what this means in practice and how they can reach that goal. The ISO standard will support these cities and help them enhance the lives of people living there.”  

The new standard in development will also draw from other related ISO documents, and the expertise and experience, in other ISO technical committees. These include a series of standards on security and resilience and the work of ISO/TC 268, Sustainable cities and communities.

It will contribute directly to UN Sustainable Development Goal SDG 11 Sustainable cities and communities.

For more information about the standard or getting involved in its development, contact your national ISO member.

Related information

Contact

By |2019-07-12T09:30:44+00:00July 12th, 2019|Weld Engineering Services|Comments Off on New ISO standard for urban resilience in development

Imagining the future of video? Enter the World Standards Day #futurevideo contest!

Could we visit a doctor via video? How will video change education? Could holograms let us be in two places at once? What new experiences will Virtual Reality bring, and how will Augmented Reality change the way we experience the world around us?

The World Standards Day #futurevideo contest challenges entrants to imagine the future of video and capture it in a film of no more than 20 seconds.

Your video should illustrate a future scenario that imagines one of the many ways that video could impact our lives in the near or distant future.

The winner will be awarded a cash prize of 1,500 Swiss francs, and the contest’s three runners-up will each receive a prize of 500 Swiss francs. The winning videos will be decided by a public vote.

The deadline for submissions to the contest is 20 August 2019. Contestants are welcome to submit up to three entries.

Find the rules of the contest and details on how to submit your entry.

The contest’s Facebook page will provide interactive guidance to potential entrants throughout the course of the contest.

The contest’s Twitter account will announce key dates and point followers to relevant supporting information.

video standards create a global stage - WSD 2019

Video standards create a global stage

The #futurevideo contest is part of the build-up to World Standards Day, 14 October, which this year takes the theme: “Video standards create a global stage”.

World Standards Day, 14 October, is an international day of observance recognized worldwide since 1970. Coordinated by IECISO and ITU, World Standards Day celebrates the collaborative efforts of the thousands of public and private-sector experts that dedicate their time and expertise to the development of international standards.

The innovation of recent decades has driven a huge leap forward in video quality. And video has also become more accessible, helping people worldwide to share their stories in vivid, moving pictures. These gains in both the sophistication and accessibility of video are built on International Standards.

The video compression algorithms standardized in collaboration by IEC, ISO and ITU have been honoured with two Primetime Emmy Awards, recognizing that these standards are central to industry’s ability to meet rising demand for video, one of the most bandwidth-intensive applications running over global networks.

Learn more about the theme from the World Standards Day 2019 message.

Related information

  • Coding of audio, picture, multimedia and hypermedia information
  • Cinematography
By |2019-07-11T13:21:41+00:00July 11th, 2019|Weld Engineering Services|Comments Off on Imagining the future of video? Enter the World Standards Day #futurevideo contest!

Travel in depth with the latest ISOfocus

Whether you’re headed to the Amazon, the Seychelles or the local lake, your journey starts here.

“Tourism is expected to keep growing as a sector over the coming years,” says Dirk Glaesser from the World Tourism Organization in an interview for ISOfocus. “The number of international tourist arrivals surpassed 1.4 billion in 2018, with the sector worth USD 1.5 trillion.”

The July/August 2019 issue of ISOfocus highlights the fastest growing trends in travel and tourism, including sustainability and medical tourism. It features everything from sustainable travel to eco-friendly retreats to diving do’s and don’ts to big adventure activities.

What we unpack in this issue is the contribution of ISO standards to solving many of today’s travel-related challenges, including the need to accelerate sustainable practices and production patterns. It explains the economics of the travel industry to create jobs, boost a country’s economy and raise living standards while protecting the best a country has to offer.

Javier García, CEO of the Spanish Association for Standardization, writes in his introductory remark: “Today, tourism standards have evolved into real tools that help organizations better position themselves on the market, increasing their competitiveness and contributing to the 2030 Agenda for Sustainable Development, the United Nations blueprint for a more sustainable world.”

Whether you’re looking for inspiration for your next holiday or want to see what’s new in travel standards, you’ll enjoying reading this ISOfocus. Browse for travel trends and read all about standardization successes here.

Cath’s travel diaries 

Looking for more travel titbits? You’re in luck! If you are prone to catching the travel bug, and your feet itch to discover new places, follow Cath’s journey on social media as she travels around the world looking for tourism standards from 10 July to 9 August. For those who care about our impact on the planet, who want to experience new thrills with no compromise on safety, and think that travel should be accessible to all, you’ll find the hottest standards and stories from our members around the world. 

Follow us: #travelstandards

Related information

Contact

ISOfocus magazine
You will find international topics covering everything from IT and transport to personal stories and everything in between.
By |2019-07-09T07:42:22+00:00July 9th, 2019|Weld Engineering Services|Comments Off on Travel in depth with the latest ISOfocus

Heading abroad for health

With the current level of income disparity between nations, even those geographically close to one another, it is hardly surprising that the provision of public services can vary a great deal from country to country. This is nowhere more the case than with healthcare, in which the relatively new phenomenon of “medical tourism” is already booming.

Paul Webster, 43, from Highbury, London, is a seasoned medical tourist who has travelled abroad for a variety of procedures over the last five years. These include cosmetic surgery in Thailand, a knee arthroscopy in India following a rugby injury, and a slipped disc in Cape Town, South Africa, where he spent his recovery time relaxing by the pool. Paul opted to go abroad for surgery as he was able to avoid a waiting list at his local hospital and the cost of treatment was around 30 % of the cost of private treatment at home. More recently, having struggled to find a good local dentist, Paul’s dental clinic is now in Krakow, Poland – a low-cost flight away.

It’s not something most people would choose to do unless they really had to. Illness, short or long term, is unpleasant and painful enough, but to travel whilst ill would, to many people, seem unconscionable. And yet, to many more, it is exactly what must be done. Quite simply, if an individual’s home country is unable, for whatever reason, to provide the requisite healthcare, why should they not seek it elsewhere? Medical tourism, as it has become known, is a booming and massive industry.

The organization Patients Without Borders estimates that “the market size [for medical tourism] is USD 65 to 87.5 billion, based on approximately 20 to 24 million cross-border patients worldwide spending an average of USD 3 410 per visit, including medically-related costs, cross-border and local transport, inpatient stay and accommodations”1). By any consideration, therefore, medical tourism is already a huge market and one that, in the short and medium terms, is only likely to grow.

Dentist showing patient's teeth on X-ray.

Healthcare elsewhere

A word should first be said about what exactly is meant by the phrase “medical tourism”. Monica Figuerola Martín has been the Managing Director of Spaincares (the Spanish Health Tourism Cluster) for the last two years, as well as General Director of Tourism in the Government of La Rioja for 12 years; she also holds a PhD in tourism. As Convenor of working group WG 2, Health tourism services, of ISO’s technical committee on tourism (ISO/TC 228), which is developing the future ISO 22525, an International Standard for medical tourism, she is keen to draw a distinction between “medical tourism” and “touristic medicine”. At its simplest, the latter is “when someone is travelling and falls ill or has an accident and has to go to hospital”. She prefers the word “travel” because tourism is something more superficial – but when someone travels for medical reasons, they are not tourists, they are patients. The primary motivation is to travel for medical treatment not available in their home countries. Indeed, it is for this reason that Figuerola Martín would prefer to go even further and for the phenomenon to be referred to as “medical travel”, for the avoidance of any ambiguity at all.

So what are the most common conditions for which people become medical tourists? The short answer to this seems to be almost anything. Patients Without Borders publishes a long list of illnesses and conditions: from non-life-threatening cosmetic surgery and dentistry to cancer and reproductive care. And it is precisely because there are so many different treatments now on offer for so many different conditions that International Standards are so vital for the world’s medical travellers.

Another question closely related to this, of course, is why do people travel for medical care? The obvious answers are the high costs for treatment and lengthy waiting times for medical procedures in many countries, supported by easier and cheaper international travel. But these are not the only reasons. Some patients value the better quality of the medical infrastructure in certain countries and undergo measures that cannot legally be offered at home, such as fertility treatment for those who want children.

Sometimes, a particular country may have an excellent reputation for treatment of a certain condition and patients may even opt for a medical trial that is not taking place anywhere else in the world, let alone their home country. 

Sometimes the reason for travelling can be something as seemingly banal as the weather: many people find dialysis, for instance, much more comfortable when they can receive treatment beside the sea and under a sunny blue sky.

Doctor and nurse with tools in their hands in a operating room.

Staying safe

So what challenges does medical tourism face and how can International Standards help? Safety is without doubt the top priority. Most of the treatments under offer are very expensive and many countries propose various and varying medical treatments. However, this does not mean that every country is offering the same, let alone best, treatments. Safety needs to be improved along with protocols because as far as it is possible within the parameters of any given procedure, there needs to be a guarantee that the treatment is going to be successful, that the patient experience is going to be the best it can be.

More broadly, there is a huge number of stakeholders in medical tourism and the value chain for medical tourism is long and often complex. It stretches from the very first moment a company contacts a hospital to request a quotation to post-treatment when the patient goes home. There are very many critical points along the way and it’s important for certain countries to develop this kind of business – as long as it is undertaken in a very secure way.

Yosr Nefzaoui, Project Leader of ISO 22525 on medical tourism, is the manager of Tunisia-based travel agency SAFAR – a subsidiary of the Service Medical International Group (SMEDI) which has been operating in Africa since 2007 – as well as holding the presidency of the Medical Tourism Committee at the Tunisian Federation of Travel and Tourism Agencies. She points out that Tunisia is receiving many patients from North and sub-Saharan Africa where the healthcare systems are not meeting the needs of patients.

Tunisia’s current stance on healthcare is very impressive, in both the public and private sectors. A brief look at the statistics says it all: there are 115 health clinics, with 4 700 beds, 100 haemodialysis centres, 150 diagnostic X-ray centres, 232 laboratories for medical analysis, over 5 300 GPs’ surgeries, over 1 600 dental offices and nearly as many pharmacies. And yet it is probably fair to suggest that Tunisia does not have the reputation in healthcare in the same way that countries like Germany and Switzerland do. These two countries are renowned for being organized and efficient but there is no real reason why Tunisia, and similar countries, should not receive some recognition and that is where International Standards will bring so much benefit.

Doctor doing a heart ultrasound to a man-patient.

Keeping up with market needs

The first step in the development of an International Standard is to confirm the market demand and it has been long established that the number of people travelling for healthcare has increased dramatically in recent years. As a consequence, there has been a crying need to develop International Standards which define, at international level, the minimum quality requirements for the whole process. Medical tourism introduces a range of attendant risks and opportunities for patients, along with many stakeholders. ISO 22525, still in draft, but to be published very soon, will focus on intermediaries in the value chain where control is non-existent but where the risk is high.

To avoid any harm to the health of travellers, all players in the value chain should comply with certain requirements in order to limit the risks. International Standards will define the very broad range of requirements for various sectors concerned, from the organization of the stay by travel agencies to the quality of care delivered by the healthcare facilities.

In this case, the International Standards under development are focused on four areas:

  • Pre-travel and pre-treatment process
  • Treatment process
  • Post-treatment process
  • Return home and follow-up

Clinical excellence

Elderly woman being comforted by a female doctor before an MRI.For the end users, this standard aims to restrict the healthcare participants who do not respond to these norms, thereby limiting the risks and ensuring better care. Paradoxically perhaps, patients may often have little idea about the concept of “standards” and are probably unaware that they are required by health centres and other stakeholders. But it is for these centres that International Standards are so important because they are taking more and more patients from abroad. Centres of healthcare need certification, otherwise governments will simply refuse to recognize them. Medical excellence along with international accreditation are the key factors fuelling a majority of international patient flows, continually boosting international medical tourism.

Overall, standardization of the patient’s experience of medical tourism will improve the quality of care and patient safety as well as the satisfaction of the patient. This can be of great value not just to patients but to all stakeholders, and to all of us. And, as so often, the committees who draft and deliver International Standards are undertaking vital – and in the case of medical tourism, perhaps even life-saving – but invisible work.


 1) Patients Beyond Borders: “Medical Tourism Statistics & Facts”, (accessed April 2019)

Related information

Contact

 

This news comes from the ISOfocus

By |2019-07-09T07:26:22+00:00July 9th, 2019|Weld Engineering Services|Comments Off on Heading abroad for health

The colour of sustainable tourism

As tourism outpaces other industries – international tourist arrivals increased by 6 % in 20181) – the sector is experiencing a revitalization. Adventure, responsible and green travel are reinventing the way communities, ecosystems and economies interact. We examine how ISO standards are supporting this trend.

Tourism creates jobs – lots of them. In fact, 1 person in 10 is employed in a tourism-related job. As travellers become more prosperous, and travel more accessible, it is estimated that the tourism sector could outperform the global economy over the next decade. It’s no surprise, therefore, that most destinations seek to expand their tourism sector for a larger slice of the pie.

Group of men and women rafting on a river.The tourism industry is also important in building a culture of peace between countries and is ideally placed to contribute to many of the United Nations Sustainable Development Goals (SDGs) working towards a fairer, more equitable world. When it is well managed, tourism provides an incredible economic boost to host communities. Yet negative effects on the environment are inherent to the industry. With increasing numbers of travellers flocking to the same sought-after locations, resulting in overcrowding and stretched facilities, the emission of greenhouse gases, waste generation and degradation of local ecosystems are almost impossible to control.

For all the many destinations that have tourism strategies in place to help alleviate poverty and conserve their natural and cultural heritage, just as many world heritage sites, which are recognized by UNESCO for their outstanding universal value, have no adequate management plan to prevent the adverse impacts of tourism. This begs the question: can tourism ever be sustainable? ISO is working towards that end.

It all started on a peninsula…

The Sinai Peninsula embodies adventure tourism. Every year, millions of tourists flock to this triangular desert for its sunshine, famous coral reefs, and to trek within its mountainous interior. Martin Denison, a keen scuba diver, first visited the Sinai desert 40 years ago. He aimed for the Red Sea, a haven for divers because of its breathtaking coral reefs and captivating multicoloured fish. Denison made his passion for the deep a profession, as a trainer, instructor and dive leader. His work later led him into standards development, becoming the convenor of the ISO working group that developed 11 ISO standards for diver safety, training and dive centres. These standards have since become the lingua franca for divers and diving centres worldwide.

In recent years, Denison has headed a working group in ISO technical committee ISO/TC 228 for sustainable tourism to develop two new standards focused on sustainable diving. The numbers for Sharm El Sheikh – the small city at the tip of the Sinai Peninsula – vividly explain why we need these standards. “Forty years ago, there were just a handful of buildings there and three diving centres in the whole peninsula,” recalls Denison. Now Sharm El Sheikh is a city with an international airport, dozens of hotels and a population of over 70 000. “About 1.6 million divers and snorkellers visit Egypt every year and now there are around 300 diving centres,” he says. The Sinai alone boasts 141 diving centres, as well as some 130 liveaboard diving boats, to meet the demand for underwater adventures.

Tourist attraction in Egypt. Scuba diving in the Red Sea on the coast of the island of Tiran is a tourist attraction in Egypt, where instructors are promoting diving techniques that preserve and protect coral reefs.

A deep dive into the world of standards

Diving, like any other outdoor activity, can have significant environmental impacts if not controlled. As the sport has increased in popularity, this in turn has highlighted the need for sustainability, or the diving sector will undermine the aquatic foundations that support it.

With that in mind, under Denison’s convenorship, a dedicated working group in ISO/TC 228, Tourism and related services, is busy preparing two standards for sustainable diving. The first standard, ISO 21416, Recreational diving services – Requirements and guidance on environmentally sustainable practices in recreational diving, describes what diving centres and services need to do to conserve and even enhance the aquatic environment. The standard includes several examples of best practice, such as how diving centres need to conduct activities (e.g. deterring divers from feeding or removing aquatic life) or how to operate boats in a way that does not damage the environment. For example, ISO 21416 specifies that boat pilots must use moorings instead of anchors, which can damage corals.

People snorkeling in blue waters above coral reef, Sharm-El-Sheikh, Egypt. Snorkelling sites in Egypt are famous the world over due to the diversity and abundance of coral reefs.

The second standard, ISO 21417, Recreational diving services – Requirements for training on environmental awareness for recreational divers, is based on the premise that if divers are aware and understand the environmental impacts of diving activities, then they will be better placed to control them. So the standard describes how divers can either eliminate or minimize both potential and actual negative risks to the environment. It also formalizes the theoretical knowledge that instructors and divers need to receive before and during the dive, and will form the basis of training courses.

Additionally, the standard outlines the positive impacts divers can have on the environment, such as using their diving skills to clean up waste, take part in surveys of aquatic life and create artificial reefs. “We wanted to address activities that other standards did not cover,” explains Denison, “such as proper conduct of diving activities, like operating dive boats. The standard will also describe how to interact with aquatic life; for example, not collecting, hunting or feeding aquatic life,” he adds. Moreover, it will include measures for conserving heritage sites, such as wrecks and artefacts, which are popular with divers.

So how will diving centres and training providers apply ISO 21416 and ISO 21417? The Ministry of Tourism in Egypt, for example, employs a number of inspectors to assist diving centres in meeting the requirements of the many ISO standards for recreational diving. “The new sustainability standards will be no exception, as I am convinced that diving operators are well aware that tourists are much likelier to return to an intact, pristine underwater environment than to one that has suffered from bad practices,” emphasizes Denison.

The working group developing ISO 21416 and ISO 21417 has been widely represented. “We have had representatives from training organizations, diving centres, the consumer protection sector, marine biologists and other scientists. We were also happy to have the professional input of a United Nations Environment Programme group called Reef-World, which developed the Green Fins standard for responsible diving near coral reefs. They were very positive about the final drafts,” he enthuses.

Family snorkeling underwater.

Eco-friendly retreats

Like many holiday destinations, the settlements of the Sinai Peninsula have grown rapidly into large resorts. All these buildings can have significant environmental, social and economic impacts. For this reason, at the end of 2018, ISO published ISO 21401, Tourism and related services – Sustainability management system for accommodation establishments – Requirements, a new International Standard that helps the hospitality industry reduce its impact on the environment, promote social exchange and make positive contributions to local economies. This standard is based on the same High-Level Structure now applied in all ISO management standards, such as ISO 9001 and ISO 14001, meaning it can be easily integrated into any existing ISO management system.

So what prompted its development? The answer lies across a continent and an ocean to the west of Sinai. In the early part of this century, there were growing concerns about the negative impacts that the tourism sector, especially hotels, could have on the environment and society in Brazil. Alexandre Garrido, the Convenor of the working group that developed ISO 21401, takes up the story. “ISO 21401 was built based on Brazilian standard ABNT NBR 15401, which the Brazilian hotel industry has applied since 2006,” he explains.

“In 2003, we launched a project to look at sustainable tourism and decided to start with hotels. We formed a wide-ranging group including travel specialists, representatives from the hotel sector, trade associations, NGOs, communities, government and agencies, deciding to approach sustainability through management systems,” explains Garrido. The working group considered best practices, embedded these within a management system structure and the result was ABNT NBR 15401.

The Brazilian standard was so successful that ISO/TC 228 adopted it as a basis for the new ISO standard. The aspects covered by ISO 21401 include biodiversity, energy efficiency, conservation, waste management, effluents, emissions, water use, resources, work conditions, cultural aspects and the needs of native populations. “ISO 21401 is a specific sustainability management system standard that covers all dimensions of sustainability, providing a modern vision for accommodation management,” concludes Garrido.

Sustainable adventures

Along with diving, ecotourism and other types of adventure travel have mushroomed. So in 2018, based in a proposal from Portugal, ISO published ISO 20611, Adventure tourism – Good practices for sustainability – Requirements and recommendations. This standard describes how adventure tourism organizations can operate sustainably and promote benign practices for both participants and local communities. Environmental sustainability, for example, can be upheld by careful planning and risk assessment, such as using renewable energy sources, having an awareness of waste regulations and areas with fragile ecosystems.

ISO 20611 also demonstrates how communication between the host, participants and local communities can be used to raise awareness of sustainable practices such as recycling, as well as informing the local community as to why adventure tourism is beneficial. For example, operators may wish to educate the local community in skills that enhance the tourism industry, which in turn further strengthens relationships.

So what types of environmental impacts motivated ISO/TC 228 to develop the standard? “In both adventure and ecotourism there is a potential risk to increase the flow of tourists in destinations without the necessary measures in place to mitigate negative impacts in these areas, especially fragile ecosystems. The standard both promotes the conservation of natural habitats as well as developing respect for the communities who receive tourism,” explains Leonardo Persi, who led the working group that developed ISO 20611. In other words, the standard fosters a win-win.

Tourists, pilot and guide on a boat excursion, Pantanal, Brazil. Boat excursion for wildlife watching in Pantanal, Brazil.

Pillars of performance

Like ISO 21401 for sustainable accommodation, we can discover the origins of ISO 20611 in Brazil, supported by similar proposals from Portugal’s national standards body. “In 2004, we were having a growing number of accidents, including fatalities. At that time, the Brazilian Ecotourism and Adventure Tourism Association (ABETA), together with the Ministry of Tourism and SEBRAE – the Brazilian Micro and Small Business Support Service – decided to develop new standards in adventure tourism to address these risks. This work is ongoing and, today, we have 38 Brazilian national standards for adventure tourism in the portfolio of ABNT, ISO’s member for the country,” explains Persi.

The first standards focused on safety, such as a management system standard for adventure tourism (ISO 21101) and a standard dealing with information to participants (ISO 21103). However, since 2014, sustainability has made an increasingly bigger image on the tourism radar, so Persi and other like-minded people began working on the combined environmental, social and economic theme, the three main pillars of sustainability. The result was ISO 20611.

Back view of tree teenagers riding horses. Horse-riding in the Pantanal, the world’s largest tropical wetlands ares, located mainly in Brazil, is a popular tourist activity.

“This new standard brings good practices for adventure tourism activities, specifies requirements and provides recommendations to apply them,” adds Persi. So how have travel companies received the standard? According to Persi, the tourism sector and its stakeholders are highly cohesive in Brazil. He reports that travel companies in particular support and apply standards. “The first paradigm was to ensure that small companies – which make up 98 % of the sector – could successfully apply the standards,” he explains.

That way, all interested parties had their role in the adventure tourism and ecotourism market, making it possible to offer participants a better service. “Besides that, if all adventure tourism operators conserve the environment, then we can maintain the communities involved and work to improve the social, cultural and biodiversity of the places adventure tourists visit,” he concludes. Exploring the world is a privilege and it needs to be sustainable so we don’t destroy the very things that make it so appealing and rewarding.

By all accounts, tourism has the potential to be sustainable, with the goodwill of all and a little help from ISO standards.


1) “International Tourist Arrivals Reach 1.4 billion Two Years Ahead of Forecasts”, UNWTO press release, 21 January 2019

Related information

Contact

 

This news comes from the ISOfocus

By |2019-07-09T07:26:22+00:00July 9th, 2019|Weld Engineering Services|Comments Off on The colour of sustainable tourism

Trust me, I’m a total stranger…

Put in these terms, most of us would run a mile, whatever the proposition. But the popularity of online reviews, and the trust we place in persons unknown when making major decisions about where to stay, what to eat and how to get the most from a trip, tells a different story.

Online communities have always been a place where people connect with peers: people like us, sharing something in common. Accessible anywhere and generally free to participate, it’s little wonder that news groups, forums and chat rooms flourished from the beginning of the internet and prepared the ground for the late 2000’s social media explosion.

It’s hard to imagine a world without these connections. They’ve become part of the fabric of our daily lives. They’ve changed not only the way we socialize and define our friends, they’ve altered our relationship to information and how we form, and express, our opinions. They’ve also influenced the way we make our vacationing decisions; many of us now move from idea through research to booking entirely on screen.

With the planet at your fingertips, why travel at all?

The digital world in our pockets fills the gaps once reserved for idle contemplation with wonderfully addictive and immersive experience. Work, relaxation, news, opinion, learning and entertainment bear down in a sensorial tsunami of information. It definitely broadens our horizons and can expose us to new ideas, yet it’s also an intrinsic part of the non-stop lifestyle. It comes as no surprise that we tell researchers we’re more stressed than ever before. Sometimes, it’s good to stop.

Could this be one reason why we travel more than our grandparents did? Perhaps it also explains why we seek increasingly exotic destinations where we can “get away from it all”, “unwind”, “change perspective”, even go “off-the-grid”. A recent ISO standard should help make the process of choosing and booking more reassuring.

But before you get there, you’ll have to navigate the options. These, too, have proliferated to the point of bafflement. It’s OK to be perplexed by a world where air travel is the budget option, your smartphone can almost-but-not-quite translate unknown languages for you, and the world’s largest accommodation provider doesn’t own a single building. Fortunately, there are still professional travel agencies to help you. They didn’t all go bust with price comparison and online booking. Quite the opposite. The ones that survived did so by innovation and specialization.

A new breed of travel agency has emerged, offering experiences that simply weren’t available before, using data-driven marketing to create client-focused packages. The information that these companies collect from us, including the reviews that are written and the opinions that are surveyed, are essential to their business model. In the highly competitive sector dedicated to adventure tourism, innovative companies use analysis and insights to give their customers what they really want: not just holidays, but life-changing journeys into the unknown. In France, one of the best-known operators is Nomade Aventure. It was founded in 1975 but, true to its name, it has never stopped moving and is now an established leader.

Screen laptop showing the site of a hotel.

Grasping an opportunity

In between sending 12 000 people per year on their dream holiday, managing a team of 60 people and travelling to discover new destinations, Nomade’s General Manager, Fabrice Deltaglia, is constantly on the go. A French national, Deltagliaʼs career has carried him on an unusual journey through film distribution in Africa, youth activity holidays and, for almost a decade, to head up a leading travel company. ISOfocus managed to pin him down to ask him about the role of standards in his life and in his company’s success.

“I came to standards by chance. When I was given the opportunity to contribute to a standard for online ratings, I knew how important it could be for our business.” I ask him in what ways: “Nomade has been using online reviews since 2011, as a way of maintaining our presence in the highly competitive online tourism business. We had our own rigorous systems in place, for example, the publication of all reviews, favourable or otherwise, for a minimum of five years, or the fact that our employees are not able to remove or edit customer reviews.”

To Deltaglia, it was clear that developing similar guidelines to be applied to all kinds of online businesses would improve transparency and maintain customer confidence in the authenticity of reviews. “It was a mix of personal curiosity as well as the recognition that we could protect our business that led me to accept an offer to participate in standardization,” remarks Deltaglia on how he began his work with the French member for ISO, AFNOR, which was the driving force behind the idea to develop a standard for online review.

French innovation goes international

In 2014, ISO set up a technical committee on online consumer reports, managed by AFNOR, to begin the development of an International Standard that would give requirements and recommendations for the principles and methods for review administrators to apply in their collection, moderation and publication of online consumer reviews. Published in 2018, ISO 20488 builds on the initial work by AFNOR, whose efforts have resulted in significant uptake by businesses in France.

Directions signpost with distance to many different countries, cities and places.Applicable to all types of business, ISO 20488, Online consumer reviews – Principles and requirements for their collection, moderation and publication, has special relevance to those sectors, like tourism, where customer experience is an overwhelming factor in decision making. It’s also a major influence when it comes to buying products that have to perform in a certain way, such as sporting goods, according to Laurent Petit, Chair of ISO’s technical committee for online reputation (ISO/TC 290), which is managed by AFNOR. With a background in mathematics and marketing, Petit brings substantial experience of business to his ISO job. Having worked in some of the best-known companies in France, from the national lottery to national television, to multinational sports superstore Decathlon, Petit’s latest challenge is with Thailand’s biggest retailer. ISOfocus caught up with him during a taxi ride through the busy streets of Singapore.

A lifelong footballer who has worked in Paris, Shanghai, Singapore and recently moved to Bangkok, Petit had some experience of ISO standards from working with a professional football club. His first opportunity as a standards development insider came when he was approached in 2014 by AFNOR. With support from colleagues who recognized, like Petit, the enormous potential of the standard, he set out to take a look “behind the scenes of the standards world”, in his words.

Asked about the rationale behind ISO 20488, Petit replies that “online review is too important to be left to chance” and goes on to point out just how central it is to today’s shoppers. “It’s a driver of conversion [moving from browsing to purchase]” citing studies that indicate how credible reviews can boost this rate by a factor of four. “There’s a growing distrust of official sources of information and manufacturers’ claims are perceived as less credible than the voice of a regular user, even if that opinion comes from someone you don’t know personally.”

Solutions to real-life problems

A final observation from Petit reveals the “there-are-only-solutions” attitude of a true standardizer: “When it comes to online reputation, the important thing is not whether a review is positive or negative, it’s how you react.” According to Petit, responding quickly and sincerely to negative feedback and, importantly, trying to fix the problem, builds more credibility than simply promoting or responding to positive reviews.

Couple talking to a female receptionist.The implications go far beyond tourism. Online review is at the heart of the decision-making process, even in cases where the actual purchase may be done in-store. With a standard like ISO 20488, which can be so widely applied to different sectors, the ISO principle of seeking an equally wide range of expertise really pays off. ISOfocus spoke with Patrick Harkness, a contributor to ISO 20488 who brought perspectives from outside of both retail and tourism.

Currently enjoying a highly active retirement (during which he both founded an emergency planning consultancy and took on a number of ISO jobs), Harkness began his career as a surveyor and specialist on major infrastructural projects in his native British Columbia. It was following this that he began working on province-wide emergency preparedness programmes : taking into account a wide range of opinions, working with multiple stakeholders and creating plans and guidance created a solid foundation for his later work in standards.

The standardizer’s perspective

Having volunteered substantial time to both national and international standards, in areas as diverse as security and resilience, vulnerable consumers and ageing societies, the ISO member for Canada – the Standards Council of Canada (SCC) – saw Harkness as a natural choice among Canadians to participate in the development of ISO 20488. He recalls: “As my volunteering expanded, SCC asked if I’d like to Chair the Canadian Mirror Committee (CMC) related to [ISO/TC 290] online reputation. I accepted, and the success of our efforts resulted in ISO 20488.”

Since we’re talking about user reviews, I’m curious to find out more about his experience of the ISO process itself. When many at retirement age are winding down their professional life, how did he find the challenge of taking on significant new responsibilities and processes? “My strengths are related to administering and organizing,” Harkness tells me, adding: “it was a natural fit for me to become a working group manager1). Having been successfully balloted into that position, I was fortunate to be sponsored by SCC to attend ISO’s Committee Managers’ Training in 2016. That was something so worthwhile and should be a ‘must-do’ for anyone agreeing to be manager of either a technical committee or working group.”

Two young men sitting at an airport lounge using a mobile phone.

“Barnaby’s article changed my life!”

It’s pretty easy to write your own review. In a virtual world, saying what you’d like to hear isn’t exactly the same thing as telling bald-faced lies, but it’s not far off. For the legions of people who make their living from enticing us to browse, click and buy online, the temptation to get over-creative in interpreting data, or paraphrasing testimonials, needs to be reined in. Without the kind of guidance given by ISO 20488, even legitimate operators can get carried away. There is genuine uncertainty of the rules in an online landscape saturated with enhanced images, virtual videos, chat-bots and an imperative to monetize your every move.

The question for online marketers to ask is whether they can make the right decisions without the framework given by ISO’s standard on online consumer reviews? Consumers place trust in standards and are quick to abandon companies that are called out on false claims. Worse, they can publish their own negative reviews and can obliterate in a few characters a reputation that may have taken years to establish.

For holidaymakers, and in fact purchasers of any kind of product or service that’s been rated, International Standards now provide an additional level of assurance. That’s lucky, because you can’t always trust advice from your friends, especially when they’re total strangers


1) Previously known as “secretary”.

Contact

 

This news comes from the ISOfocus

By |2019-07-09T07:26:22+00:00July 9th, 2019|Weld Engineering Services|Comments Off on Trust me, I’m a total stranger…

Brazil’s big adventure

If you are looking for new sensations on a tourism trip, Brazil offers options you just can’t miss. As adventure tourism grows in popularity, we asked Ricardo Fragoso, General Officer at ABNT, ISO’s member in Brazil, why the country is fast becoming a world reference for outdoor activities.

What are the two direct assets of tourism? In addition to physical infrastructure, nature and culture are also key elements when it comes to sustainability in the business, helping to offset poverty in local populations. As regards its tourism industry, Brazil is still proving itself. With an area of 8.5 million km2 and over 200 million inhabitants, the country is seeking a route to socioeconomic viability and, more recently, for ways to conserve its natural environment.

This is an arduous task, but the determination of the government and the Brazilian people has overcome many of the problems by working together to lead the country towards a future of development and prosperity. In this context, sustainable tourism presents itself as one of the forces capable of contributing to economic development while, at the same time, helping to preserve Brazil’s priceless natural heritage.

Canopy tree climbing in the Amazon rainforest. Adventure tourists use well-secured cables to enjoy tree-top views in the Amazon rainforest in Brazil.

Adventure tourism in one of the most important markets in international tourism, and Brazil’s huge territory and environmental variety means that it is able to offer unique opportunities for nature tourism and open-air leisure activities. According to the Ministry of Tourism, in 2018 the country received almost seven million international visitors, which produced over USD 3.2 billion of foreign currency revenue in the first six months alone. Domestic tourism, for its part, totalled over 200 million travels, although these only refer to around 60 million people.

Today, Brazil’s tourism industry generates income for nearly seven million people, mainly in fields related to accommodation, tourism agencies, airlines and other types of transportation, as well as restaurants and leisure facilities. But in order to make Brazilian nature tourism a commercial success, there needs to be investment in quality infrastructure, the training of guides, and in providing safe and efficient services at a fair price. Otherwise, tourists will choose other destinations.

Leading the way

A great deal has already been done: our technical standard for adventure tourism has been globally recognized by governments worldwide and used as the basis for the first international regulations for safety management in adventure tourism – ISO 21101. It’s a source of great national pride that most of the standards for adventure tourism published so far by ISO are based on Brazilian standards developed by ABNT, ISO’s member for the country, and the work of the Brazilian Ecotourism and Adventure Tourism Association (ABETA), a not-for-profit civil entity that brings together ecotourism and adventure tourism companies whose main goals are working in a professional, sustainable and innovative way.

Photo: ABNT

Ricardo Fragoso Ricardo Fragoso, General Officer at ABNT, ISO’s member in Brazil.

Prior to that, in 2008, a partnership between ABNT and the Ministry of Tourism had given the industry free consultation of technical standards. The tourism minister of the day, Marta Suplicy, justified the initiative by explaining that “nowhere in the world can adventure tourism exist without standardization”. These International Standards have helped Brazil expand its field of activity by drawing on technical and safety resources for best practice in adventure tourism. In addition to three ISO standards on adventure tourism, Brazil has also adopted 11 ISO standards on recreational diving and plans to incorporate two more in its portfolio.

All this standardization work caught the attention of big players in the adventure tourism market, such as managers of nature reserves and forests, public managers and other stakeholders, who are now interested in implementing sustainable practices. We currently have 38 Brazilian standards published for this segment, making Brazil a world reference for safety in ecotourism and adventure tourism.

Big adventures, small footprint

Sustainability is one issue that has been at the centre of our discussions in ISO. The most recent standard published is ISO 20611, Adventure tourism – Good practices for sustainability – Requirements and recommendations, which takes a long view of the sector’s challenges in order to protect the natural environment by minimizing any potential negative effects and engage local communities through better-paid jobs.

But most of all, sustainability is about strengthening the tourist experience in the place of destination while valuing local communities’ culture and customs. To that end, Brazil will soon be endorsing as a national adoption ISO 14785 on tourist information centres, which can be used by tourist offices across the country to deliver better service to visitors with quality information on the Brazilian hotspots most favoured by tourists.

The national adoption of ISO International Standards has brought considerable added value to Brazil’s adventure tourism segment. For instance, the scale and extent of accidents have been significantly reduced and tourists are more aware of the safety protocols for accident prevention, which include the high-quality training of guides involved in outdoor activities, often in very remote locations.

Little beautiful girl climbs on rope harness in a summer city park.

Putting safety first

The Brazilian government, through the Ministry of Tourism, has put the emphasis on safety. Brazil’s Safe Adventure Program is an initiative of the Ministry of Tourism in partnership with Sebrae, an organization dedicated to small business empowerment, and ABETA, Brazil’s adventure travel tourism association. Under the programme, companies must obtain a safety certificate in adventure tourism to guarantee that visitors can indulge in outdoor activities in a sustainable way and with the most rigorous safety standards.

Standards also have an impact on local suppliers and all those working in emergency services. As part of the ABNT safety management system, an emergency service plan has done wonders to enforce the implementation of a management system, mainly among small companies, which account for 98 % of businesses in the adventure tourism sector. Tourists are always willing to pay a little more for activities that are carried out to strict safety standards, with skilled professionals and equipment that is subject to regular and stringent maintenance, as they see the added value of the tourism product that is being offered.

Since its implementation in 2005, the Safe Adventure Program has helped many companies integrate the good practices of technical standards. These include Campo dos Sonhos and Parque dos Sonhos, two rural retreats in the São Paulo area that boast an integrated system combining both sustainable accommodation and safety in adventure tourism. Today, they are seen as a reference in Brazil in terms of sustainable adventure tourism, with a comprehensive offering that comprises services to disabled visitors or those with limited mobility, as well as a host of activities for children, teenagers, families and the elderly.

Boat trips to the waterfalls of Lagos de Furnas, Minas Gerais, are a popular tourist activity in Brazil.

Nas Alturas, a specialist eco-tour operator in the Chapada Diamantina, also caters for travellers looking for safe and environmentally responsible tours in the area. Offering everything from day hikes to longer overnight excursions to explore the region’s unique natural beauty, the company enforces safety standards and disseminates good practices to its entire network of activity providers. Nas Alturas is an impressive example of a sustainable tourism initiative that promotes social inclusion through encouraging local hires, the conservation of natural resources and the respect for cultures and peoples as a means of stimulating local economic development.

Standardization has, by all accounts, improved the way tourism is being offered in Brazil. The country has earned itself a place in the adventure tourism segment by offering an array of companies that meet international quality requirements. This consolidates a soft adventure circuit capable of attracting and welcoming national and international tourists, all converts to the idea that Brazil is more than just beaches and sun.

Related information

Contact

 

This news comes from the ISOfocus

By |2019-07-09T07:26:22+00:00July 9th, 2019|Weld Engineering Services|Comments Off on Brazil’s big adventure

Progress in Active Ingredient Formulations

The study of medicine has a long history, with the first records of physicians in Egypt (Hesy-Ra the first recorded male physician in ca. 2700 BCE; Peseshet the first recorded female physician in ca. 2400 BCE) and important examples of prescriptions for medications (for example the Ramesseum medical papyrus in ca. 1800 BCE; the Kahun Papyrus in ca. 1800 BCE; the Ebers Papyrus in ca. 1550 BCE and the Edwin Smith Papyrus, 1500 BCE) also from Egypt. Important contributions to medicine have been made by researchers worldwide, with Nobel Prizes in Physiology or Medicine awarded to researchers from Africa, Asia, Australasia, Europe, North America and South America (see Table I).

Table I

First Examples of Nobel Laureates in Physiology or Medicine from Specific Geographic Regions

Year Laureate Country Justification Geographic region
1901 Emil Adolf von Behring Germany For work on serum therapy Europe
1902 Ronald Ross UK, India For work on malaria Europe, Asia
1923 Fredrick Grant Banting, John James Rickard Macleod Canada, UK For the discovery of insulin North America, Europe
1945 Alexander Fleming, Ernst Boris Chain, Howard Waiter Florey UK, Australia For the discovery of penicillin Europe, Australasia
1947 Carl Ferdinand Cori, Gery Theresa Cori, Bernardo Alberto Houssay USA, Argentina For their discovery of the course of the catalytic conversion of glycogen North America, South America
1951 Max Theiler South Africa For discoveries concerning yellow fever and how to combat it Africa

While early medications were all natural products, the industry supporting the production of medications on large scales is inextricably linked to the chemical sciences, with companies in Europe (for instance, Merck & Co, Bayer and BASF in Germany; Ciba-Geigy, Roche and Sandoz in Switzerland; and Beecham Group, GlaxoSmithKline, Burroughs and Wellcome in the UK) and the USA (Eli Lilly and company, Pfizer and Squibb) making important early contributions (1). While the scale of the industry and complex developments in regulations and mergers are outside the scope of this review, it is noteworthy that the industry has a hugely beneficial economic impact (worldwide the pharmaceutical industry employs millions of people and has a revenue that exceeded US$1000 billion every year from 2014) and health and societal impacts (such as improvements in life expectancy).

The success of this industry is contingent on significant investment in research and development (R&D) processes (2). The bioactive molecule discovery process involves identification of lead compounds plus design and synthesis of variants to screen their therapeutic potential. The bioactive development process is used to establish the suitability of the bioactive manufacturing process, including: appropriate design of synthetic route answering such questions as whether it is affordable and if the building blocks are available from a reliable source, identification and toxicology of intermediates and impurities (3). Early stage bioactive discovery (technology readiness levels (TRLs) 14) is carried out by researchers in academia and industry; late stage development (particularly to increase the selectivity, bioavailability and therapeutic efficiency of the compounds) (4) is most often carried out by industry, with formulation studies and in vitro and in vivo validation studies carried out either in house or outsourced to an academic or industrial contractor prior to clinical trials in collaboration with health services (for example, the National Health Service (NHS) in the UK) and regulatory bodies depending on the specific market (5). The bioactive molecule industry is constantly evolving to deal with national and international regulations and the scrutiny of healthcare organisations (6). New synthetic strategies and analytical and computational techniques allow for the exploration of an ever-wider range of bioactives which pose both challenges and opportunities for companies active in this highly competitive market.

The remainder of this review will focus on the formulation of AIs in agrochemical and pharmaceutical formulations (also known as active substances, bioactives, bulk actives, APIs and drugs), primarily for application to humans (cognisant of the vast market for formulations of bioactives for agrochemical and veterinary applications and different requirements in terms of formulation methodology and regulations).

Organisms are controlled on the cellular level by a multitude of bioactive molecules. It is highly likely that throughout an organism’s lifetime one of these systems will falter due to disease or injury and a therapeutic API could be employed to aid in the recovery of normal function (7). The complex nature of an organism’s cells and physiology provide many opportunities for API intervention (for instance, specific intracellular functions) when required to affect the desired response (7). APIs have a therapeutic window (as depicted in Figure 1). Below the therapeutic window we observe the subtherapeutic region in which an API is ineffective at providing the desired effect, whereas above the therapeutic window unwanted side effects and toxicity may be observed (8).

Fig. 1.

Examples of release profiles

Examples of release profiles

The formulation of APIs to deliver quantities of the API within the therapeutic regime is of key importance to their clinical translation and success. Formulations can be divided into two broad categories: non-synthetic formulations (the most common) where the API is used unmodified in combination with other ingredients in order to achieve the desired effect (see Table II for examples); or synthetic formulations, where the API is synthetically modified to impart the desired properties, for example, prodrugs (14). Formulations need to be tailored to suit their route of administration such as inhalation, injection, oral or transdermal. For humans, oral intake is by far the most popular, providing fast release, cost effectiveness and relatively high patient compliance (15). The fast release provided by traditional methods of API delivery such as inhalation, injection, oral and transdermal can be beneficial for pain relief, however they often require the patient to take a relatively high dose of an API to ensure a small amount of the API reaches the desired location to elicit the desired therapeutic response (16). This may also result in issues related to API clearance from the body (metabolised or excreted via the renal system) which can limit the duration the API is within the therapeutic window. Other factors including the biological and physicochemical properties of the APIs (such as solubility and absorption) (17, 18) and patient compliance (of growing importance with ageing populations worldwide) highlight the market need for controllable API delivery systems for medical or veterinary applications, similarly for agrochemical applications (19). Indeed, API delivery systems that reduce the number of administrations required offer potentially significant economic, health and societal impacts (20).

Table II

Examples of Clinically Translated Stimuli-Responsive Formulation Systems

Stimulus Treatment Reference
Radiation Radiotherapy (9)
Light Photodynamic therapy (10)
Electricity Electroconvulsive therapy (11)
Ultrasound Sonograms (12)
Infrared Thermography (13)

Researchers based in industry and academia have therefore invested significant effort in the development of API delivery systems to address these issues, which are often classified generationally, with first generation delivery systems developed between 1950–1980, second generation delivery systems developed between 1980–2010 and third generation delivery systems developed from 2010 onwards (2123). The first case of controlled API release was published by Smith, Kline & French, USA, when they demonstrated the ability to release dextroamphetamine (Figure 2) over a 12 h period in 1952 (24). The success of this breakthrough prompted an investigation of new controlled API delivery systems designed to reduce intake to once or twice a day and mechanisms of API release (osmosis, ion-exchange, diffusion and dissolution) (25). By understanding these release mechanisms it was possible to begin to control the physicochemical characteristics of API delivery systems and thereby the release profiles of the APIs. While first generation API delivery systems delivered their payloads at a predetermined rate that was often short and did not account for patient needs or varying physiological conditions (8), second generation API delivery systems are characterised by attempts to control the level of API within target tissues above the minimum effective level for prolonged periods. The maintenance of the minimum effective level is important not only to ensure the benefit of the API to the patient over an extended period of time, but also to prevent the onset of side effects and immune responses. An interesting example of this is a formulation capable of sustained release of quetiapine (Figure 2, which is used in the treatment of schizophrenia) that has reduced the administration regime to a single dose per day, diminishing problems with patient compliance (26, 27).

Fig. 2.

Examples of chemical structures

Examples of chemical structures

Second generation API delivery systems also include examples capable of delivering high molecular weight APIs (peptides, proteins and DNA) potentially from hydrogel- or nanoparticle-based API delivery systems, that were optionally cell-targeted or stimuli-responsive (25). The third generation API delivery systems are characterised by efforts to: deliver poorly soluble APIs; tightly control release kinetics (for example via application of one or more external stimuli); and overcome biological barriers (such as the blood-brain barrier) (23, 25).

An ideal API delivery system would be a source of a specific amount of API to a precise location with temporal control, thereby allowing maintenance of a minimum effective level of the API for the duration required to have its therapeutic effect (illustrated in Figure 1) (28). Different situations require different API release profiles and application- or patient-specific API delivery profiles are desirable for the medical, veterinary and agrochemical industries (29).

API delivery systems incorporating polymers have been developed for first, second and third generation of delivery systems and polymers of various architectures are key components of both non-synthetic (such as aerosols, dispersions, emulsions, foams and suspensions) and synthetic formulations (for instance, as a polymer prodrug). The pioneering research of Robert Langer and coworkers underpins the development of polymer- based drug delivery systems (DDS) in academic and industrial settings (3032). Polymer chemistry and engineering to tailor the structures of polymers for specific applications is an area of intense ongoing research interest (33), particularly with a view to developing API delivery systems that provide control over the quantity, location and time of API delivery (34).

Polymer-based API delivery systems can enhance the duration of activity for APIs with short half-lives (28). API delivery systems that encapsulate a payload of API and break down at a predictable rate can be utilised for a variety of therapeutic agents, particularly when displaying a moiety that targets the API to specific cells or tissues (35). Poly(ethylene glycol) (PEG, Figure 2) is a polymer often conjugated to macromolecular APIs (commonly known as PEGylation) (36) to enhance their half-lives by reducing their rate of clearance via the renal system and eliciting minimal inflammatory response (37).

The utilisation of biodegradable and bioerodible polymers such as poly(caprolactone) (PCL, Figure 2), poly(D,L-lactic-co-glycolic acid) (PLGA, Figure 2) and PEG that respond to enzymes such as esterases and lipases are now very popular as a result of their biocompatibility in vivo reducing the immune response and averting systemic toxicity (38, 39). Cisplatin (Figure 2) (40) is a common anticancer API that has proved effective in the treatment of a variety of tumours however its inherent toxicity and resistance limitations have prevented the full potential of this API being reached (41). A recent study into the construction of platinum(IV)-encapsulated prostate-targeted nanoparticles of PLGA-PEG functionalised with prostate-specific membrane antigen (PSMA) targeting aptamers was found to help optimise the delivery of a lethal dose of cisplatin to prostate cancer cells (41). The use of these polymeric agents in this manner not only provides controlled breakdown of the DDS giving slow release of the API but also provides specific targeting of cancer cells.

Other physicochemical triggers (for instance, pH) are also of interest for API delivery systems. Cancer cells are associated with a lower pH (normally ca. 5/6) than normal cells thus making pH sensitive API delivery systems desirable as damage to healthy cells can be minimised (42). Likewise, the acidic milieu within dental caries-producing biofilms are another situation in which pH can be a useful trigger for oral drug delivery (43).

Oral API Delivery Systems

Oral administration of APIs necessitates the stability of the API and its respective acidic and basic components in the digestive tract and effective permeation of cell membranes (44). Ion-exchange systems have been investigated for their ability to act as API delivery systems, wherein once the API reaches the gastrointestinal tract the body’s salts displace the API allowing it to pass through the cell membrane in a controlled manner (20). However, human physiology makes API delivery via gastrointestinal (GI) tract challenging (45). The short GI transit time (ca. 12 h) makes the delivery of macromolecular therapeutics such as proteins and nucleic acids difficult (45). The limitations of API delivery in the GI tract (44) have helped to shape the development of polymer-based API delivery systems to deliver macromolecules such as insulin orally or via inhalation (46, 47).

An ideal API delivery system would allow a patient to monitor and administer drugs (such as insulin) on demand with control over the dose and no need for invasive injections. Variations of these are currently being developed for the self-regulated treatment of diabetes (48).

Transdermal API Delivery Systems

Transdermal patches were amongst the first systems to be available to patients with APIs being attached to an adhesive patch before delivering a specific dose through the patient’s skin and into the bloodstream (49). Transdermal patches enable controlled release via a porous membrane slowly releasing an API from a reservoir within the patch. The first transdermal patch was FDA approved in 1979 for the delivery of prescription API scopolamine (Figure 2) for the treatment of motion sickness (50). Nowadays, many APIs are administered via transdermal patches (for example, Daytrana®, EMSAM®, Exelon® and fentanyl, Figure 2) covering a wide range of medical conditions from Alzheimer’s to attention deficit hyperactivity disorder (ADHD) (51).

Whilst API delivery from transdermal patches is effective, the skin is a barrier to entry from external bodies which results in a high proportion of the API being prevented from entering the body and a reduced therapeutic efficiency (49). One solution to this problem is the utilisation of chemical enhancers (49) to alter the permeability of an API, for example, the skin permeability of oestradiol (Figure 2) can be increased twenty-fold via formulation with ethanol (52). A common side effect of the use of chemical enhancers is skin irritation at the site of the patch which may make the use of the enhancer non-viable. Another method is to chemically modify the structure of the API to improve its permeability; however, this can be difficult, expensive and time consuming (53). The use of arrays of microneedles for transdermal delivery is increasingly popular because of their broad applicability and minimal pain (54).

The use of microneedles in drug delivery began in the 1990s as a result of the emergence of microfabrication techniques that enable their manufacture (55). Microneedles are used in a variety of medical systems including skin pre-treatment for increased permeability, drug coated needles and drug encapsulated needles (55). Microneedles are now widespread in drug delivery having shown the ability to give controlled release of a wide range of low molecular weight drugs and vaccines (55). The delivery of the influenza vaccine using a microneedle is common in modern medicine (56). Microneedle delivery depends on a variety of factors including skin permeation, drug stability, drug storage and patient response (55). This emerging field of medicinal chemistry shows great promise in forwarding the field of drug delivery.

Injectable and Implantable API Delivery Systems

Injectable and implantable API delivery systems are particularly useful for conditions requiring the delivery of APIs to specific sites within the organism. Many APIs suffer from an inability to reach the required site of action due to a biological barrier (for example, the blood-brain barrier). Parkinson’s disease caused by dopamine deficiency cannot be treated by administration of dopamine because it does not cross the blood-brain barrier, however, the prodrug levodopa (Figure 2) is capable of crossing the blood-brain barrier after which it is metabolised to dopamine (Figure 2) (57).

Likewise, <2% of the administered dosage of naltrexone (Figure 2), an API used in the treatment of opioid dependence reaches the brain and naltrexone-polymer conjugates can increase the amount of API working at the site of action resulting in US Food and Drug Administration (FDA) approval for use for the treatment of alcohol dependence (2006) and opioid dependence (2010) (58).

Implanting API delivery systems at or near the desired site helps to maximise local delivery and minimise undesirable side effects. A polymer-based API delivery system known as Ocusert which controls the release of pilocarpine (Figure 2) and reduces pressure in the eyes (59); implantation of pilocarpine encapsulated between two polymer membranes controlled the release at a rate of 20 mg h–1 for up to a week (59). Several polymeric versions of the Ocusert delivery system exist, all capable of delivering pilocarpine in a controlled manner with differing release profiles. Early uses of this system were limited by poor biodegradability, however, new formulations of biodegradable polymers have helped to improve degradation profiles (60).

Biodegradable polymers (such as poly(anhydrides) and polyesters) used for polymer-based API delivery systems can slowly degrade and release APIs (for example, carmustine (Figure 2) a chemotherapeutic treatment for brain cancer) and carmustine-loaded polyanhydride films directly at the tumour site were shown to significantly improve patient survival rates when treating glioblastoma multiforme (61).

PGLA has also been used in the controlled delivery of the API apomorphine (Figure 2) which is used in the treatment of Parkinson’s disease (62). Apomorphine has poor oral availability and a short half-life, resulting in multiple administrations being required which limits its widespread usage, therefore controlled release methods are used to overcome this shortcoming (62). The use of PGLA prevents the burst release of apomorphine and increases longevity of the API within the target tissues (62). This system demonstrated controlled release of the API over ten days, releasing 90% of the payload.

Stimuli-Responsive API Delivery Systems

The investigation of smart devices in medicine has probed the use of API delivery systems that can control API release using an external stimulus or by interactions between the API delivery systems and changes in their environment. By implanting a biocompatible device within the patient and then triggering API release externally, the patient would be provided with the therapeutic benefit over an extended period of time. An ideal API delivery system would allow control of the dosage, timing, duration and site of API release, resulting in delivery of the therapeutic agent in a remote and non-invasive manner. A range of stimuli can be used to trigger API release including pH, infrared (IR) (63), ultraviolet (UV)-visible light (64, 65) magnetism (66), temperature (67), ultrasound (68), electric fields (69) and radiation (70). Many of these stimuli are already utilised in clinically translated API delivery systems (Table II). The development of API delivery systems that respond to these stimuli and provide the controlled release of loaded APIs potentially improves treatment efficiency and diminishes or prevents the onset of side effects. There are API delivery systems that respond to multiple stimuli to further improve selectivity for specific functions (71), see below for a fuller discussion.

Another emerging aspect of formulation science involves the use of shape memory materials (SMMs). SMMs demonstrate plastic deformation when stimulated by an external stimulus and return to their original shape upon removal of the stimuli (72). Shape memory polymers (SMPs) are stimuli responsive compounds which are able to demonstrate mechanical action in response to a range of stimuli depending on the material make up. SMPs offer a range of advantages including; wide glass transition states, tailored stiffness, high shape recovery, high elastic deformation, biodegradability, biocompatibility and low thermal conductivity (72). The ability of these materials to assume a specific shape upon triggering can be utilised for drug delivery. PCL and poly(lactide) (Figure 2) are often utilised in medical SMPs as they have distinctive glass transition states and are inherently biodegradable and biocompatible (73). The use of these polymers in SMPs can assist in drug delivery via two mechanisms: either the shape recovery of the polymer enhances drug release or the polymer facilitates delivery of the drug delivery device to the body in a minimally invasive manner (73). The incorporation of a drug into a SMP delivery system has been demonstrated to affect performance of the DDS however controlled release is still possible. The use of SMPs in urethral stents has been demonstrated using the SMP as a method of controlled release of anti-inflammatory drugs (74). This method demonstrated the ability of SMPs to show controlled release of a drug and upon completion degradation into non-toxic products (74). This example highlights the potential use of SMPs in drug delivery and wider medicinal applications (75).

Light-Responsive API Delivery Systems

Light triggered API delivery systems are very popular in the literature due to their ability to provide temporal and spatial control, functioning via various mechanisms including photochemical, photoisomerisation and photothermal (76). Photodynamic therapy (PDT) is one of the most well-established techniques and uses light in the UV-visible spectrum to treat skin and throat cancers (77). PDT is less effective when attempting to affect deeper set tumours such as prostate and liver cancers for which light in the IR spectrum is preferable as a result of its relatively low absorption by mammalian tissues (63).

Photochemical API delivery systems release a therapeutic payload upon covalent bond cleavage in response to light irradiation (76). An example of such chemistry is the cleavage of an o-nitrobenzyl ester derivative releasing a carboxylic acid (Figure 3). The carboxylic acid-displaying molecule was released over several hours at surface power of 1.3 mW cm–2, however when increasing the power to 20 mW cm–2 release was only observed over 5 min (78). This system demonstrates a high degree of control that shows promise in being utilised in API delivery studies.

Fig. 3.

Photochemical cleavage of an o -nitrobenzyl ester yielding an o -nitrosobenzaldehyde derivative and an API displaying a carboxylic acid

Photochemical cleavage of an o -nitrobenzyl ester yielding an o -nitrosobenzaldehyde derivative and an API displaying a carboxylic acid

A library of photo-responsive units have been explored for API delivery including coumarin, pyridylmethyl esters and porphyrins, all of which contain readily cleavable covalent bonds (79). Photo-responsive API delivery systems function on the requirement of light with a wavelength that possess sufficient energy per photon to affect the breakage of covalent bonds (80), making UV (81) and visible light (79) popular triggers. One of the most prevalent problems with light triggered API delivery systems is the relatively poor tissue penetration of UV and visible light, this has been addressed by the development of near-infrared (NIR) API delivery systems (82). NIR is only fractionally adsorbed by biological tissues thus allowing it to trigger API release in deeper areas of the body (82). Almutairi et al. report the use of a UV responsive nanoparticle DDS in which nintedanib (Figure 2), a drug used in the treatment of idiopathic pulmonary fibrosis, is released over ten weeks (83). The nanoparticles were shown to be biocompatible with no adverse effects observed despite the extended period of implantation (83).

Photo-responsive hydrogel-based API delivery systems (84) offer the opportunity to deliver sensitive bioactive macromolecules (84) and minimise the body’s immune response. A recent trend in the literature points towards the development of systems that do not require the use of UV as a result of the risk it poses to the skin and eyes. The use of NIR and visible light triggered systems are increasingly popular in photochemical API delivery due to reduced risk associated with these triggers (85).

Whilst a great deal of progress has been made in the field of photochemical API delivery many problems still persist and must be overcome before these systems are fully utilised in modern medicine. Early attempts at photochemical triggering often resulted in one effective dosage of the API before the system is empty, however new innovative systems have demonstrated pulsatile delivery with few adverse effects. Tissue penetration is still a problem in this field with visible light-based systems limited to the skin, throat and nose (63). As with all new systems being introduced to the body, biocompatibility is a huge stumbling block. Even the most biocompatible systems generate some form of immune response, sometimes in the form of inflammation but others can be more serious and so systems must be vetted fully before use. Despite these problems, photochemical API delivery remains a very popular research area with huge progress being made throughout this field.

Electro-Responsive API Delivery Systems

Early attempts to develop stimuli responsive systems included the development of conducting polymers which were theorised to be able to release an API upon triggering with an electrical stimulus. Polypyrrole (PPy) in its conducting (oxidised) form allows oppositely charged ions to be doped into the polymer backbone which was pioneered by the Miller Group in 1984, who demonstrated their ability to release glutamate ions (Figure 2) via the reduction of PPy (Figure 4) films (86). The cationic PPy is doped with anionic or neutral API molecules. When an electric current is applied to the system the polymer changes redox state and the API is released in order to charge balance the system (87).

Fig. 4.

Redox switching of PPy releasing API dopants

Redox switching of PPy releasing API dopants

The sensitivity of electroactive species can be manipulated to create a range of API release profiles through redox switching. Despite the widespread usage of PPy as an API delivery agent it is difficult to process due to its poor solubility in most solvents. Many attempts have been made to improve the solubility of PPy with limited success (88). PPy is also non-biodegradable and therefore can be difficult to remove from the patient’s system once all the loaded API has been used (89). The success of utilising PPy films as API delivery agents prompted an investigation into other polymers such as polyaniline (PANi, Figure 2) (90) and poly(3,4-ethylenedioxythiophene) (PEDOT, Figure 2) (91) with varying degrees of success. The biocompatibility of the polymers and the amount and molecular weight of API that can be loaded onto these films are areas of current research (92, 93), as is the generation of biodegradable versions (94, 95).

Multi-Responsive API Delivery Systems

Whilst single stimuli responsive systems are very useful, they are restricted to certain release profiles based on the stimuli in question. The complex nature of the human body and the conditions which affect it often require additional more complex solutions than single stimuli-responsive DDS. Multi-stimuli responsive DDS are being explored for their ability to create more varied release profiles, providing an improvement in tuneability and selectivity versus single responsive systems (96). In theory multi-responsive DDS allow for the treatment of a wider range of complex conditions by regulating release by one or more stimuli based on patient needs (96).

When constructing multi-responsive DDS separate units, each of which is responsive to a specific stimulus, are blended together without affecting each unit’s responsiveness. Several systems are currently in development based on the ability of one stimulus to act as a targeting moiety whilst the other stimuli are responsible for producing a response in the desired tissue.

pH is one of the most commonly used stimuli in dual responsive DDS. The ability of these systems to be selective based on the targeting of the lower pH of cancer cells makes them desirable in modern cancer treatments (97100). pH is often combined with a variety of other stimuli including light, electricity and magnetism to create a desired response in cancerous tissues. pH and light responsive materials are popular dual responsive DDS. Nie et al. have demonstrated the ability of these systems to show controlled release of the chemotherapy agent doxorubicin hydrochloride (Figure 2) via photothermal drug release (101). The use of a pH responsive group ensured selectivity towards cancer cells over healthy cells with an NIR responsive group providing photothermal release of doxorubicin hydrochloride in a controlled manner (101).

Dual responsive DDS which incorporate multiple stimuli capable of creating the desired drug release response are less common, however several examples exist in the literature. Argouz et al. have developed such a system with the use of sodium alginate gel beads in a pH or magnetic drug release system (102). In this system pH sensitive sodium alginate is combined with methyl cellulose which has shown to be responsive to magnetic fields. Sodium alginate is a biodegradable, biocompatible, non-toxic polysaccharide and can be readily modified making it a useful tool in drug delivery (103). It has been combined with chitosan, pectin and gelatin for use in drug delivery with all systems displaying a high degree of biocompatibility (103). The resulting material has demonstrated the ability to show controlled release of the anticancer drug 5-fluorouracil (Figure 2) over extended periods of time (102). This system is comprised of both a targeting stimulus and two active delivery stimuli providing a high degree of impact when attempting to affect cancer tissues.

Kyriakides et al. took a different approach to multi-responsive DDS being able to generate constructs via simultaneous electrospinning and electrospraying, generating compartmentalised storage of multiple drugs (104). The use of this method provides a PCL fibre structure with a hyaluronic acid core, allowing drugs to be loaded in the polymer film (104). Further studies have shown the ability to trap other spheres of drug within an electrospun mat, allowed for delivery of multiple drugs with differing solubilities demonstrating various release profiles (104). A minimal immune response was found when using pirfenidone (Figure 2), an anti-fibrotic drug, in one of the release compartments (104).

Multi-responsive systems are becoming more prevalent in the literature with many systems demonstrating effectiveness in drug delivery, particularly when attempting to affect cancerous tissues. This field will continue to grow as scientists find more ways to incorporate more stimuli into existing systems, providing ample opportunity to treat a variety of conditions and improve patient care. Some examples for APIs displayed in Figure 5 and Figure 6 are highlighted in Table III.

Fig. 5.

Examples of APIs formulated in controlled delivery systems highlighted in Table III

Examples of APIs formulated in controlled delivery systems highlighted in Table III

Fig. 6.

Examples of APIs formulated in controlled delivery systems highlighted in Table III

Examples of APIs formulated in controlled delivery systems highlighted in Table III

Table III

Examples of API Formulations

Future Outlook and Conclusions

Significant progress has been made in the field of API delivery over the past sixty years and the scope of controlled API delivery systems has greatly increased. Many challenges still remain in this field, such as delivering APIs to specific cells, targeting genes and designing systems to cross complex barriers such as the blood-brain barrier (42). New materials are being developed aimed at improving biocompatibility, generating new release profiles and improving patient care (142). Continued investment and effort in this field will lead to the development of API delivery systems capable of the delivery of APIs to specific tissues to the benefit of patients and the healthcare industry.

Advancements in the field of API delivery and controlled release have had a direct impact on other fields of chemistry such as synthetic and polymer chemistry, chemical engineering, materials science, chemical biology and bioengineering (33). Many API delivery systems exist generating a variety of release profiles and targeting different conditions. Conditions can now be treated at the required site of action leading to more effective treatments and broadening our understanding of biological mechanisms that affect diseases. Despite the increase of treatments and the deepening of our understanding of API release, clinical needs are still unmet and many challenges still remain. Administrative demand has forced new methods of API delivery to be formulated that protect sensitive molecules as well as targeting deep set regions of the body which are often unreachable by oral delivery systems. Advances in synthetic chemistry have allowed for the development of new classes of therapeutic agents that aim to address administrative demands and in tandem with materials science, have allowed release of APIs to occur over extended periods to treat chronic conditions.

The field of controlled delivery of APIs is broadening with new emerging concepts such as systems based on three-dimensional (3D) printed technologies and gene delivery systems becoming useable alternatives (143).

It is important that we continue to strive for a greater understanding of the human body and the DDS we are trying to input. We can begin to exploit expressions exhibited by specific diseases to improve targeting and tailor our systems to maximise therapeutic efficiency. The field of API delivery forms the intersection of chemistry, materials science, medicine and bioengineering. This has proved to be an extremely fruitful area with wide scope for exciting future work.

By |2019-07-08T07:40:13+00:00July 8th, 2019|Weld Engineering Services|Comments Off on Progress in Active Ingredient Formulations

Continuous Production of Squalane Using 3D Printed Catalytic Supports

Home > Journal Archive > Continuous Production of Squalane Using 3D Printed Catalytic Supports

Johnson Matthey Technol. Rev., 2019, 63, (3), 191

Introduction

SQA is a colourless, odourless and tasteless hydrocarbon oil notably resistant to oxidation. It is known to act as an immune system stimulant as well as antioxidant agent. These properties are contributing to it increasingly being used in the pharmaceutical industry. For instance, emulsions of SQA with surfactants are added to vaccines to enhance the immune response (1). A number of studies have proved the properties of SQE and SQA as an antioxidant, drug carrier and emollient (2). The pharmaceutical industry uses SQA in vaccines and in anticancer treatment. SQA and SQE have been proven to have very little toxicity and improve the antibody responses to antigens in a number of primates (3).

Due to its capability to penetrate the human skin, SQA is best known for its applications in the cosmetic industry. The main interest is to transport and increase absorption of other active components (4). The main uses of SQA are shown in Figure 1.

Fig. 1.

Uses of SQA in 2014

Uses of SQA in 2014

The use of SQA is preferred for all of these uses to SQE as this molecule is stable and not susceptible to oxidation (5).

SQA is produced from hydrogenation of SQE, which is a non-saponifiable component of natural lipids. The reaction is shown in Scheme I.

Scheme I

SQE used to be obtained from shark liver oil, although this practice is generally not accepted by cosmetic manufacturers. Today most of the SQE is derived from vegetable sources, such as olive oil and sugarcane. The cost of SQE as well as the impurities present in the reactant depend on the source, as shown in Table I.

Table I

SQE Purity and Cost Depending on Source

SQE source Content, % Cost, € kg–1 Impurities after hydrogenation
Shark liver oil 98–99 17–19 Not significant
Olive oil 5–17 21–24 Sterol esters Parafins
Sugar cane 92–93 22–27 Isosqualane Monocyclosqualane

The purity of SQE will affect the selectivity towards SQA. For instance, a range of different purities of SQE were studied by Pandarus et al. (4). Results showed that under the same reaction conditions, high purity SQE (98 wt%) achieved 99% selectivity towards SQA, whilst in a lower purity sample (82 wt%) the selectivity was 39%.

This hydrogenation is traditionally carried out in a batch reactor with the use of a nickel based catalyst (6) or more recently palladium catalysts (7). The disadvantages of the traditional process are the fast and irreversible Ni catalyst deactivation and Ni leaching that requires product purification. The cost of the hydrogenation of SQE comprises ca. 40% of the total price of the entire process (8). Therefore, a new catalyst that would overcome disadvantages of the traditional process might bring considerable cost savings. Nevertheless, the other challenge of this reaction is its extreme exothermicity (ΔHr = –604.26 kJ mol–1). It is therefore important to consider that the intensified catalytic system will generate more reaction heat, which needs to be removed from the process.

This paper presents results on hydrogenation of SQE in a continuous reactor with use of newly developed catalyst on a ceramic 3D printed support to improve the process from the points of view of both catalyst activity and heat transfer.

The intensification of a catalytic reactor is mainly dependent on the operational limitations of the system and requirements related to the specific chemical reactions. For that purpose, working on the geometry of the catalytic support is one way to reach the desired improvements, which implies the definition of an adequate approach to design such 3D structures.

In a continuous flow reactor, the catalyst needs to be shaped in a form that suits both the process and chemical reaction itself. The shape must consider factors such as mass transfer limitations and reduction of selectivity due to side reactions (9). Packed beds of shaped supports tend to be used in continuous reactors. However, a common problem due to the nature of the shape packing is their associated pressure drop (10) as well as possible flow maldistribution. The latter can result in reactants not accessing the surface of the catalyst uniformly decreasing the overall performance of the process, for instance, by causing wide distribution in residence time that lowers selectivity (9).

Digital methods allow objects to be designed and produced for specific applications. Optimised structures offer the possibility of efficiently controlling the fluid dynamics and temperature uniformity (9). The work presented in this paper uses modelling of the flow phenomena involved in the hydrogenation of SQE to produce a 3D structure that optimises the process.

Catalysts Used in this Study

The catalyst support was based on a ceramic precursor that is commercially available in the form of cylindrical pellets and served as a benchmarking material for the developed 3D printed catalysts. The catalysts were prepared by 3D printing to provide a precursor that was consequently thermally converted to the ceramic of a desired structure. The structure was then impregnated with Pd. A novel preparation method was developed in Johnson Matthey, UK, to ensure high dispersion and high stability for Pd on ceramic. A summary of the physical characteristics of the samples is shown in Table II.

Table II

Catalysts Used for Hydrogenation of SQE

Catalyst 3 mm pellets 1 mm pellets 3D printed (crushed) 3D printed
Form Extrudates (cylinders) Extrudates (cylinders) 3D structure crushed 3D structure
Particle size 3 x 3 mm 1 x 3 mm Irregular particles 1–3 mm 1 x 3 mm
Shape

All the catalysts were supplied by Johnson Matthey and consisted of 2 wt% Pd developmental samples. The testing was carried out using 3.5 mmolPd per 100 g of SQE.

Different particle sizes of conventional extrudates were used in an attempt to study the effect of diffusion limitation. Subsequently, the conventional and 3D printed ceramics were compared using crushed 3D printed supports sieved to the same size as the conventional pellets. In the case of crushed 3D printed catalyst, the crushing process preceded the catalyst impregnation to avoid its distribution inhomogeneity.

Design of 3D Printed Supports for a Continuous Reactor

Tailored supports were designed for the hydrogenation of SQE in a continuous reactor. Because of the extreme exothermicity of this relatively fast reaction, it is desired to control the reaction rate in a way to avoid formation of a narrow reaction zone or hot spots especially at the first part of a reactor. One of the possible ways to achieve this would be to vary the metal loading on the support. However, increasing the loading could encourage the agglomeration of Pd particles and lead to rapid deactivation of the catalyst. An alternative way was to use 3D printing technology for the design of catalytic foams with different density. This, in turn, resulted in a way of keeping metal loading per gram of catalyst while varying the amount of metal in a certain part of the reactor.

Firstly, the structure topology of the support was chosen. Open-cell foams were selected because this type of structure can incorporate attractive benefits, such as suitable thermal conductivity, depending on the chosen material, appropriate mixing, low pressure drop and large surface area per unit volume to increase catalytic activity. Besides these benefits, open-cell foams also offer the advantage of being the repetition of a representative unit cell, which can significantly simplify its manufacture and the modelling of the physical phenomena involved. There is a set of information required to fully define the geometry of a system containing an open-cell foam support: (a) topology of the representative unit cell; (b) values of relevant geometric parameters of the cell; (c) total number of unit cells present in each direction (x, y and z ), i.e. dimensions of the system (overall or sections).

In the specific case of this work, twisted cubic cells were chosen as the base topology due to their simplicity. The geometric parameters to consider were the unit cell width, struts’ diameter, twist angle per unit length of foam and tilt angles of the cells relative to the main flow direction.

A set of foam geometries were tested based on different values of the referred parameters. For each foam, a sequence of steps was followed to assess the best options:

  • (a) Digital representation of the foam structure in a stereolithography (STL) file (see Figure 2). This file format can be used for both 3D printing and to perform computational fluid dynamics (CFD) modelling. The STL files were produced by a geometry generator software based on the input of the previously mentioned information. The geometry generator used was Blender® (Blender Foundation, The Netherlands), a free software package that can work in automatic mode using script files programmed in the Python language

  • (b) Creating a proper computational mesh for the fluid volume. This volume is complementary to that defined by the STL file (solid volume). The mesh generator software was cfMesh, a tool of OpenFOAM® (The OpenFOAM Foundation, UK)

  • (c) Performing a CFD simulation in the mesh previously created (step (b) above) to characterise the foam structure in terms of mixing and pressure drop (see illustrative results in Figure 3). The open source OpenFOAM® CFD package, which uses the C++ programming language, was the software used. The implemented numerical model was prepared to include single-phase flow and transient mass balance equations (with diffusion, convection and the possibility of homogeneous and heterogeneous reaction terms) for different species

  • (d) The data produced by the CFD simulation are post-processed to calculate the value of a previously defined objective function. This objective function includes terms addressing mass dispersion, pressure drop per unit length and superficial area per unit volume.

Fig. 2.

(a) Representation of one of the open-cell foams tested; (b) the corresponding computational mesh

(a) Representation of one of the open-cell foams tested; (b) the corresponding computational mesh

Fig. 3.

Illustrative results of: (a) concentration; and (b) pressure fields in the system presented in Figure 2 – central longitudinal view. The results were obtained for a simulation replicating a tracer test (tracer inlet concentration in the left side of (a)) with an average inlet velocity of 0.03 m s–1 using a mesh corresponding to about 5% of the total reactor length

Illustrative results of: (a) concentration; and (b) pressure fields in the system presented in Figure 2 – central longitudinal view. The results were obtained for a simulation replicating a tracer test (tracer inlet concentration in the left side of (a)) with an average inlet velocity of 0.03 m s–1 using a mesh corresponding to about 5% of the total reactor length

From the set of geometries investigated, the STL files of the two foams selected are shown in Figure 4. Based on these files, slices of 1 cm height were 3D printed according to both referred designs. The corresponding values of structure porosity (ɛ), specific (geometrical) surface area (AS) and diameter of struts (dS) are shown in Table III. For comparison, the properties of the beds consisting of 1 mm and 3 mm conventional pellets (extrudates) are also provided. The specific surface area of Design 2 foams is close to 3 mm pellets while keeping higher bed porosity, which is beneficial for lower pressure drop.

Fig. 4.

Representation of two STL files designed for SQA production. A full view, a front view of a central longitudinal cut and a zoom of this cut are presented for each design. The zoom view contains indication of strut diameter (dS, green) and distance between struts (dO, red)

Representation of two STL files designed for SQA production. A full view, a front view of a central longitudinal cut and a zoom of this cut are presented for each design. The zoom view contains indication of strut diameter (dS, green) and distance between struts (dO, red)

Table III

Parameter Values for the Selected Open-Cell Foam Designs and Pellets

ɛ AS, m–1 dS, mm
Design 1 0.44 (0.52a) 1080a 1.64
Design 2 0.51 (0.61a) 1420a 1.0
1 mm pellets 0.38 2894 1.0
3 mm pellets 0.40 1266 3.0

The use of two different types of structures, as shown in Figure 5, allowed the initial part of the reactor to achieve a slower rate of SQE hydrogenation, also yielding a lower temperature rise that prevents possible hot spot formation. In the second part of the reactor, more metal can be present per unit volume, which will allow the reaction to be completed to high conversion and thus high SQA yield without compromising the selectivity.

Fig. 5.

Schematic of the reactor filled with the two different types of structures, ratio of design 1 and design 2 is 1:3

Schematic of the reactor filled with the two different types of structures, ratio of design 1 and design 2 is 1:3

Catalyst Preparation and Characterisation

The catalyst was prepared by impregnation of a Pd precursor, aiming at 2 wt% Pd, on the different ceramic supports and subsequent reduction. The particle size of the Pd was derived from carbon monoxide (CO) metal area measurements. The sample was reduced under H2/N2 at 80°C for 10 min. The catalyst was then cooled under N2 to 35°C. Subsequently, pulses of CO were introduced. A Pd:CO stoichiometry of 1:1 was assumed and the Pd atomic area was assumed to be 0.0800 nm2. The Pd particle size calculated from the CO adsorption measurements was 3–8 nm (11).

The samples were examined in a JEM-2800 Transmission Electron Microscope (JEOL, Japan) using the following instrumental conditions: Voltage 200 kV; C2 aperture 70 μm (Z-contrast) imaging in scanning mode using an off-axis annular detector. The secondary electron (SE) signal was acquired simultaneously with the other scanning transmission electron microscopy (STEM) images providing topological information about the sample.

The STEM images showed the distribution of the metal in the support. Similar distribution was observed for different samples. Figure 6 shows the images corresponding to 1 mm pellets, representative of the catalysts used in the study. The bright areas indicate the location of Pd on the surface of the ceramic material. These images (Figure 6) illustrate a good dispersion and metal distribution of the metallic particles. The particle size was determined to be between 2 nm and 6 nm, similar to those observed via CO metal area.

Fig. 6.

Dark-field STEM (DF-STEM) images of Pd/ceramic catalyst

Dark-field STEM (DF-STEM) images of Pd/ceramic catalyst

The metal loading for the 3D printed catalysts was kept constant at 2 wt% Pd. The same Johnson Matthey developmental synthetic method was followed for the samples using the 3D printed support.

The metal concentration on the 3D printed foam was investigated via electron probe microanalysis (EPMA) and results for the areas illustrated in Figure 7 are presented in Figure 8. Although the centre of the foams presented lower Pd density, EPMA analysis showed metal present in the inner areas of the support, showing a gradient of concentration.

Fig. 7.

Areas studied by EPMA for catalytic foams for hydrogenation of SQE

Areas studied by EPMA for catalytic foams for hydrogenation of SQE

Fig. 8.

Metal distribution for Pd/3D ceramic printed foams: (a) A; (b) B; (c) C; (d) D (see Figure 7)

Metal distribution for Pd/3D ceramic printed foams: (a) A; (b) B; (c) C; (d) D (see Figure 7)

Results and Discussion

Batch Reactor Testing

Traditionally, hydrogenation of SQE is carried out in a batch reactor using Ni catalyst with reaction conditions changing in a series of steps. High temperatures during the first steps are typically avoided since the reaction tends to yield undesired products such as cyclosqualanes. Therefore, to obtain high SQA yields usually the temperature and hydrogen pressure are gradually increased to compensate for catalyst deactivation.

From the mechanistic point of view, hydrogenation of SQE to SQA proceeds through formation of numerous amounts of partially hydrogenated intermediates and their isomers. Using gas chromatography-mass spectrometry (GC-MS), more than 60 individual peaks of partially hydrogenated intermediates and isomers have been identified, which were divided into six groups based on their molecular weight (MW). Besides the SQE (MW 410) and SQA (MW 422) there were six groups of partially hydrogenated intermediates differentiated by one double bond (H2) giving molecular masses MW 410, MW 412, MW 414, MW 416, MW 418 and MW 420. Among the undesired intermediates, cyclosqualane (MW 420) can be found. This presented a more significant peak in the GC-MS spectrum. Catalytic performance of different catalyst shapes as well as effect of operating conditions on the hydrogenation process were investigated. For this series of experiments, 99% SQE (marine source) was used to rule out the effect of vegetable SQE impurities.

Comparison of different catalysts, using high purity SQE (99%, Aldrich) showed that the best performance was obtained with 1 × 3 mm pellets followed by 3 × 3 mm pellets and 3D printed crushed catalyst that had slightly lower performance, see Figure 9. This result indicates that most probably internal diffusion limitations take place and the effect is less important for 1 × 3 mm pellets.

Fig. 9.

SQE hydrogenation: comparison of different catalysts, 2% Pd/ceramic, 180°C, 20 bar, 10% SQE (marine) in an organic solvent

SQE hydrogenation: comparison of different catalysts, 2% Pd/ceramic, 180°C, 20 bar, 10% SQE (marine) in an organic solvent

The impact of different operating conditions is discussed below. Figure 10 shows the temperature effect on relative SQE concentration and SQA yield profiles versus time. After about 3 h of reaction, all SQE was practically converted at all reaction temperatures, while the SQA yield reached only 54.5% at 160°C or 70% at 180°C respectively. This observation most probably indicates that the apparent activation energy of the subsequent hydrogenation steps of individual C=C double bonds increases with the degree of saturation. Note that undesired side products of reaction such as cyclosqualanes were not observed under these conditions.

Fig. 10.

SQE hydrogenation: temperature effect, 2% Pd/ceramic, 3 × 3 mm pellets, 20 bar, 10% SQE (marine) in an organic solvent

SQE hydrogenation: temperature effect, 2% Pd/ceramic, 3 × 3 mm pellets, 20 bar, 10% SQE (marine) in an organic solvent

The effect of pressure is presented in Figure 11, demonstrating that the formation of partially saturated intermediates was favoured against SQE at hydrogen pressure about 15 bar. Besides, high pressure was necessary to reach high SQE yields. The parametric study in a batch reactor provided the necessary input about the optimal operating conditions to conduct the SQE hydrogenation in a continuous reactor.

Fig. 11.

SQE hydrogenation: (a) pressure effect on SQA yield; (b) intermediates (ITM) yield. 2% Pd/ceramic 3 × 3 mm pellets, 180°C, 10% SQE (marine) in an organic solvent

SQE hydrogenation: (a) pressure effect on SQA yield; (b) intermediates (ITM) yield. 2% Pd/ceramic 3 × 3 mm pellets, 180°C, 10% SQE (marine) in an organic solvent

Catalyst Deactivation in Batch Reactor

In a batch reactor, a powder version of the catalysts prepared was tested for stability. For this series of experiments, vegetable SQE was used, with a purity of 82% as it is expected that this would be more representative of the behaviour of the catalyst in the pilot plant. The reaction was carried out for 4 h at 200°C and 20 bar of hydrogen.

The experimental results are shown in Figure 12. The partially hydrogenated SQE intermediates are presented as groups according to their GC-MS MW starting from SQE and its isomers with MW 410 to SQA (MW 422). L1 represents the analyses of the reaction products using a fresh catalyst. Subsequently, L2 to L4 represent runs 2 to 4 using the same catalyst and conditions with a fresh feed. L4a, however, corresponds to the product of the reaction after thoroughly washing the catalyst with xylene. Both activity and selectivity decreased after each cycle. A significant regeneration of both SQE conversion and selectivity towards production of SQA was observed in L4a.

Fig. 12.

Product composition after repeated use of the catalyst, reaction time 4 h at 200°C and 20 bar, Pd/ceramic

Product composition after repeated use of the catalyst, reaction time 4 h at 200°C and 20 bar, Pd/ceramic

This experiment followed a thorough washing of the catalyst attempting its regeneration. A likely explanation for recovering the activity and selectivity is that the washing had removed intermediates of the reaction deposited on the surface of the catalyst. Some waxes were observed in the final product, which tended to dissolve in the feed when hot.

Thermogravimetric experiments showed the presence of a product in the used catalyst after one use that decomposed at ca. 250°C, as shown in Figure 13.

Fig. 13.

Thermogravimetric study of Pd/ceramic catalyst after one use

Thermogravimetric study of Pd/ceramic catalyst after one use

In a continuous reactor, the temperature should be kept above 85°C to avoid solidification of the waxes that occur on the surface of the catalyst.

In conventional methods for production of SQE using Ni as the reducing agent, the metal tends to leach onto the final product. In order to avoid toxic metal in the SQA, a costly cleaning step is required after reduction. Although the process presented in this paper is Ni free, it was necessary to determine whether Pd leaches into the final product. Various Pd compounds have been proven to induce sensitisation in several animal species (11). It was thus necessary to test the levels of Pd present in the final SQA. The Pd content for L1 and L4a were analysed by inductively coupled plasma mass spectrometry (ICP-MS) to show levels of the metal below 5 ppb. This proved the safety of using this Pd catalyst for a cosmetic application. Both the absence of Pd in the final product and the possibility of regenerating the catalyst, suggested that the catalyst was stable under the reaction conditions.

Continuous Hydrogenation of Squalene in a Trickle-Bed Milli-Reactor and a Pilot-Plant

A feasibility study was carried out to determine whether it would be possible to perform the hydrogenation of SQE in a continuous reactor. A trickle-bed milli-reactor of a bed volume about 10 ml was employed to perform hydrogenation tests with catalyst of conventional shape. The unit was operated for several days while each experiment at constant operating conditions took at least 6 h. At 180°C and 25 bar a stable SQE conversion 99.5% with SQE yield 69.8% was obtained (see Table IV).

Table IV

Comparison of SQE Hydrogenation Performed in Continuous Reactors of Different Scales

Unit Trickle-bed milli-reactor Pilot-plant reactor Pilot-plant reactor
Catalyst Conventional Conventional 3D printed
Reactor volume ml 10 324 324
Reactor diameter mm 8.5 22 22
Catalyst size mm Pellets 1 × 3 mm Pellets 3 × 3 mm 3D printed
SQE flowrate (20% in solvent) g h–1 5.5 185 185
Temperature °C 180 180 180
Pressure bar 25 25 25
Space velocity mmolPd h g–1SQE 20 20 20
SQE conversion % 99.5 100 100
SQA selectivity % 69.8 89 95.7

Catalyst deactivation was not observed in the trickle-bed milli-reactor. However, the transmission electron microscopy (TEM) images of the spent catalyst showed a slight aggregation of Pd particles after ca. 40 h of reaction, as illustrated in Figures 14 and 15. Once the hydrogenation process in continuous mode was proven to be feasible in the trickle-bed milli-reactor, experiments in a pilot-plant of volume 324 ml were approached under the same operating conditions.

Fig. 14.

(a) TEM image for fresh catalyst; (b) particle size analysis for fresh catalyst

(a) TEM image for fresh catalyst; (b) particle size analysis for fresh catalyst

Fig. 15.

(a) TEM image for catalyst after ca. 40 h in trickle-bed milli-reactor; (b) particle size analysis for catalyst after ca. 40 h in trickle-bed milli-reactor

(a) TEM image for catalyst after ca. 40 h in trickle-bed milli-reactor; (b) particle size analysis for catalyst after ca. 40 h in trickle-bed milli-reactor

Continuous Pilot-Plant Squalene Hydrogenation

The pilot-plant for continuous hydrogenation of SQE is an automated, computer-controlled system (which was developed and built by Advanced Machinery & Technology Chemnitz GmbH within the project PRINTCR3DIT).

With the aim of transferring the SQE hydrogenation from conventional batch to a continuous method a tubular reactor was the most suitable choice. It can be run as a trickle-bed reactor. The reactor itself is made of stainless steel. Solid catalyst can be loaded from the top of the reactor. Figure 16 represents a schematic of the pilot plant, with the reactor highlighted by the red line.

Fig. 16.

Schematic of the continuous pilot-plant for SQE hydrogenation

Schematic of the continuous pilot-plant for SQE hydrogenation

State-of-the-art Catalyst

For the purpose of a benchmark, a state-of-the-art catalyst supported on conventional 3 mm pellets form (see Table II) was loaded into the reactor. The catalyst was obtained following a proprietary synthetic method from Johnson Matthey. This was compared with a catalyst prepared using a 3D printed ceramic support. No significant pressure drop was observed between the top and the bottom of the reactor.

This conventional catalyst allowed an excellent conversion of SQE into SQA at temperatures from 180°C to 240°C with a pressure of 25–30 bar. However, adjusting the temperature to 240°C and the pressure to 30 bar resulted in high conversion with an acceptable level of isomerisation.

3D Printed Catalyst

The 3D printed catalyst as a foam (see Table II) was loaded into the reactor. The total weight of the sample was 200 g, forming a catalyst bed of 75 cm high. As for the conventional catalyst, no significant pressure drop was observed during this trial between the top and the bottom of the bed.

Conversion and selectivity were high at low temperatures with the 3D printed catalyst, which differed from the low selectivity observed when using conventional supports. The novel 3D printed catalyst showed high selectivity towards SQA at a temperature of 180°C and a pressure of 25 bar (see Table IV). A possible explanation for this improvement could be the fact that the geometry of the foam enhanced the diffusion of SQE and hydrogen on the surface of the metal.

The effect of temperature on the selectivity to SQA was also investigated, as shown in Figure 17. Operation at temperatures below 180°C allowed good conversion of SQE. However, the selectivity towards SQA becomes insufficient. Nevertheless, at 240°C excellent conversion and selectivity were obtained even for the 100 wt% vegetable SQE feed.

Fig. 17.

Conversion of SQE and selectivity towards SQA at different temperatures, at liquid feed rate 250 g h–1, 75 wt% SQE in organic solvent, 25 bar, 3D printed catalyst

Conversion of SQE and selectivity towards SQA at different temperatures, at liquid feed rate 250 g h–1, 75 wt% SQE in organic solvent, 25 bar, 3D printed catalyst

The single load of 3D printed catalyst has produced more than 15 kg of good quality SQA up to the time of writing this article with no signs of deactivation. This suggests that the catalytically active phase does not change during the process and the metal does not significantly leach into the product. The use of 3D printed technology allowed optimisation of the reaction conditions and production of large amounts of SQA using a more compact reactor than current technologies.

Conclusions

In principle, it would be possible to carry out the hydrogenation of SQE in a batch reactor with the novel catalyst developed by Johnson Matthey. However, it would require catalyst reactivation between cycles. The use of a continuous reactor presents the advantages of reusability of the catalyst with no significant losses of activity or selectivity. On the other hand, for a typical SQA production plant, a batch reactor of ca. 1.5 m3 would be required, while a continuous system could carry on the process with a volume of about 0.05 m3, 30 times smaller. Being able to control the reaction rate along the reactor bed and preventing formation of undesired isomers is a potential advantage of the use of 3D printing technology. The use of CFD modelling for the efficient design of the support proved crucial in the success of the experiments. Being able to directly print the final catalytic support offered the advantage of an alternative way to change the process, which in turn, would allow higher levels of flexibility. In addition, because of the use of a Pd catalyst, the final product was Ni free, which removed the cleaning step that would normally occur in the manufacturing of SQA for the pharmaceutical and cosmetic industries.

Acknowledgements

The authors acknowledge the financial support given to the PRINTCR3DIT project by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 680414. The project belongs to the Sustainable Process Industry through Resource and Energy Efficiency (SPIRE) programme and information can be found online. The authors would also like to thank Daniel G. Direito for preparing the STL files in Blender® and Martha Briceno de Gutiérrez and Trung Tran for the STEM images. Thanks to Gareth Hatton for the EMPA study. Finally, the author would like to acknowledge Paul Fisher and Raquel García for their study on Pd leaching.

This contribution has been prepared using results achieved within the open access infrastructure belonging to the project Efficient Use of Energy Resources Using Catalytic Processes (project code LM2015039) which was financially supported by the Ministry of Education, Youth and Sports of the Czech Republic within the targeted support of large infrastructures. The project has been integrated into the National Sustainability Programme I of the Ministry of Education, Youth and Sports of the Czech Republic through the project Development of the UniCRE Centre, project code LO1606.

The Authors


Sonia Garcia obtained a BSc in Chemistry from the University of La Rioja, Spain. She joined Johnson Matthey in 2001 where she worked on a Marie Curie funded PhD in Chemistry from the University of Reading, UK, on nanocatalysts for fuel cell applications. Currently she is working in the New Applications Group in Johnson Matthey on a variety of projects.


Stephen Poulston has a PhD in chemistry from the University of Cambridge, UK, and is a research scientist at Johnson Matthey, Sonning Common, UK where he has worked since 1998. Stephen has experience of a wide range of heterogeneous catalyst systems including hydrogenation and platinum group metal catalysis.


Deena Modeshia obtained a MChem in 2006, followed by a PhD on hydrothermal synthesis of mixed metal oxides, from the University of Warwick, UK, in 2010. She joined Johnson Matthey in 2012 and has worked on several gas purification projects and currently works on catalysts for improving the process of converting waste into useful products or hydrogen.


Petr Stavarek graduated in Chemical Engineering at VŠB – Technical University of Ostrava, Czech Republic and pursued his PhD studies at the Institute of Chemical Technology, Prague, Czech Republic. As a member of the Department of Multiphase Reactors at the Institute of Chemical Process Fundamentals of the CAS, Prague, Czech Republic, he is leader of a laboratory of microreactors. His main research interests are in microreaction technology, microreactor design and process intensification for multiphase and catalytic reactions.


Massimo Ujčić graduated in Chemical Engineering at the Faculty of Chemical Engineering and Technology, University of Zagreb, Croatia. In 2016 he joined the Department of Multiphase Reactors at the Institute of Chemical Process Fundamentals of the CAS, Prague, Czech Republic where he pursues PhD study. His research interests are in microreactor design, 3D printing and process intensification for multiphase and catalytic reactions.


Farzad Lali graduated in 2008 in Chemical Engineering from RWTH Aachen University, Aachen, Germany and obtained his PhD degree in 2015 from Dresden University of Technology, Germany. His research interests are multiphase reactions, structured catalysts and modelling and simulation. He was a postdoctoral fellow at the Department of Multiphase Reactors of the Institute of Chemical Process Fundamentals of the CAS, Prague, Czech Republic. He is currently working as a research associate at the Institute of Chemical Engineering of the University of Ulm, Germany.


Manuel A. Alves graduated in 1995 in Chemical Engineering from the Faculty of Engineering of the University of Porto (FEUP) and obtained a PhD degree in 2004 at the same institution. He is an Associate Professor at FEUP and his main research interests are in complex fluids, microfluidics and computational rheology.


José Daniel Araújo graduated in Chemical Engineering from the FEUP and obtained his PhD degree at the same institution. The PhD work involved the design, operation and modelling of a pilot scale setup based on a continuous structured packing bubble column reactor for vanillin production from lignin oxidation. He joined the Transport Phenomena Research Center (CEFT) at FEUP in 2008 and worked in several projects involving modelling and CFD applied to multiphase flow, transport phenomena and process intensification.


Michael Krusche obtained his degree in physics from the Dresden University of Technology, Germany, in 1980. He is Managing Director of Advanced Machinery & Technology Chemnitz GmbH (AMTECH), Chemnitz, Germany, which he founded in 2010 emerging from his former company AMTEC GmbH, Germany. The core competence of AMTECH is the development and production of highly automated reactor systems, with applications especially in the field of catalysis.


Frank Ullrich graduated in Chemistry at the Freiberg University of Mining and Technology, Germany, in 2003 and obtained his PhD from the same university in 2008. At the same time, he was a staff member of AMTEC GmbH. Currently, he is chief technology officer of the company and primarily responsible for the development of AMTECH systems.


Diana Maier graduated in Chemical Engineering at the Dresden University of Applied Sciences, Germany, in 2006. She joined the Leibniz Institute for Solid State and Materials Research (IFW) Dresden, Germany, where she conducted her PhD, followed by a PhD degree from the Dresden University of Technology in 2011. Since 2012 she has been a staff member of AMTECH.

By |2019-07-04T07:22:43+00:00July 4th, 2019|Weld Engineering Services|Comments Off on Continuous Production of Squalane Using 3D Printed Catalytic Supports
Go to Top