Ten steps to net zero: Academy welcomes government plans

The Royal Academy of Engineering has welcomed the Prime Minister’s announcement of a ten point plan for a ‘Green Industrial Revolution’. A resilient, net-zero recovery will be vital in setting the UK on the right pathway to meet its target of net-zero territorial emissions by 2050, as set out in the National Engineering Policy Centre’s recent paper Beyond COVID-19: laying the foundations for a net zero recovery. While the pandemic is having a damaging impact on the economy and society, it also presents a window of opportunity to accelerate progress towards net-zero through changes to our built environment and our infrastructure systems, including energy, transport and digital communications.

Academy Fellows and researchers commented on the Prime Minister’s announcement:

Professor Nilay Shah OBE FREng, Vice-Chair of the National Engineering Policy Centre Net Zero working group, said:

“This is an ambitious and broad-ranging announcement. It’s good to see a holistic approach which aims to advance our capabilities across a broad range of domains. There is a good balance of supply, demand and infrastructure interventions planned. However, delivering net-zero in a just and economically beneficial way will require a huge engineering effort, a clear understanding of how the different interventions work together as a system, and accompanying societal and behavioural change. It requires a stable commitment by government to net-zero policymaking over the long term that builds on the short-term economic recovery and responds to the scale and pace of change required.”

Dr Shaun Fitzgerald FREng, Director of the Centre for Climate Repair at the University of Cambridge, said:

“The 10-point plan is to be welcomed since we urgently need a green industrial revolution. Much of the discussion is about reducing our emissions, and this is where we need to start. However, is it enough? Once we get to net zero, with carbon capture and storage for example being used to balance the unavoidable emissions, we will still be left with an atmosphere with too much CO2. We therefore need to do more and invest in active greenhouse gas removal solutions. We need to go harder at the climate than simply getting to net zero, although of course this is a necessary first step.”

Dr Dame Sue Ion DBE FREng FRS said:

While the ten point plan is encouraging to much of the energy industry sector, it doesn’t go nearly far enough in recognising the engineering and financial challenges associated with the journey to net zero. It is also missing an essential element which engineers would immediately recognize as important and that is the systems level thinking required to generate a deliverable roadmap. Each of the areas of focus in the  ten point plan is still treated to a greater or lesser extent as a ‘silo’ with objectives and potential benefits articulated for just that element when what should be happening is consideration of the whole package as a system as they are all interlinked. For instance, while recognition is given to traditional renewables as a source of electricity to enable clean hydrogen to be produced, there is little recognition that small modular reactors potentially have a huge role to play here, not just the longer term more advanced high temperature systems.

The role nuclear power has in providing low-carbon electricity is gaining greater awareness and not before time! However, its significant potential in providing a solution to the more challenging aspects of the goal to achieve net zero has yet to receive the attention it deserves. Nuclear power offers so much more than low carbon electricity. It is vital this is acknowledged and built into the required system level thinking for meeting our future energy demands. This greater utility and generally unrecognised benefit from the heat as well as electricity offered by nuclear energy and not just the advanced systems but also SMRs, delivers real advantage compared with other low carbon energy sources provided it is driven forward to deployment.

There are huge expectations for offshore wind built into the 10 point plan but little recognition of the need to plan for times when even in the offshore environment there are days and nights when the wind is very low or isn’t there at all.

Professor Geoffrey Maitland CBE FREng, Professor of Energy Engineering at Imperial College London, said:

It is good to see a significant focus on hydrogen as this is needed as the complement to wind to decarbonise domestic heating.  Initially most of this will be ‘blue’ hydrogen made from natural gas which will need point eight, CCS, to remove the co-produced CO2. Producing hydrogen will be a key product of the green industrial clusters, being multi-purpose decarbonised transport and power as well as heating.

“Replacing our dwindling nuclear capacity, much of which is due to be decommissioned soon, is a key element of reaching net zero by 2050.  We need to reinvent and reinvest in our nuclear reactor construction industry to provide clean baseload power to complement wind and other renewables and major employment in northern England.

“The carbon capture initiative is welcome news of significant investment in a key technology without which the UK will not achieve net zero by 2050 and where the UK is playing catch-up after two failed initiatives terminated by the government in 2011 and 2015.  So it is good to see the recommendations of the 2018 CCS Cost Challenge Task Force being followed, with CCS being introduced at up to four industrial clusters involving essential but difficult to decarbonise processes, such as chemicals, cement and steel. These will be too late to impact the 4th carbon budget (2022-26) but will be essential to meet the 5th budget (2026-32) and onwards to achieve net zero emissions by 2050.  The design and construction lead time is two to three years so it would have been better to have four or more clusters given the green light now to ensure the full impact of this essential technology by the early 1930s.

“The vision for hydrogen is inextricably linked to CCS as an enabler and the graded targets towards a fully-heated Hydrogen Town by 2030 is exciting, although there is potential with more investment to roll this out in at least six locations in the same timescale.  Hydrogen, with its multiple green applications, is the ideal complement to increased wind investment.  It has the advantage that ‘blue’ hydrogen from gas plus CCS can be enhanced and eventually replaced by ‘green’ hydrogen from excess cheap renewable electricity used to electrolyse and even cheaper feedstock, water.”

Professor Ian Fells CBE FREng FRSE said:

“The affirmation that nuclear power is ‘clean energy’ and the development of a new generation of small advanced nuclear reactors demonstrates the realisation that new nuclear will play a huge part in moving to net zero carbon.”

Dr Greg Alexander, Royal Academy of Engineering Research Fellow at Newcastle University, said:

“The commitment to carbon capture in the UK is very welcome, but as this type of support has been promised before and was removed at the last minute, we must ensure that it is delivered this time. As these carbon capture projects are largely planned for regions with a long and proud industrial heritage, but where there is significant unemployment now, there will need to be further support for training and reskilling so that jobs go to people living in the local community.

“Although the announcement is heading in the right direction, it is disappointing to see no specific mention of negative emissions technologies as ultimately net zero is only a first step towards going net negative; we need to be thinking about how we do that now.”

Notes for editors

  1. The ten point plan for a green industrial revolution

Details of the plan outlined in the Prime Minister’s announcement are available in full in the government’s Ten Point Plan for a Green Industrial Revolution.

  1. About the Royal Academy of Engineering

The Royal Academy of Engineering is harnessing the power of engineering to build a sustainable society and an inclusive economy that works for everyone.

In collaboration with our Fellows and partners, we’re growing talent and developing skills for the future, driving innovation and building global partnerships, and influencing policy and engaging the public.

Together we’re working to tackle the greatest challenges of our age.

For more information please contact:

Jane Sutton at the Royal Academy of Engineering

T: 020 7766 0636

E:  Jane Sutton

By |2020-11-19T12:33:11+00:00November 19th, 2020|Engineering News|Comments Off on Ten steps to net zero: Academy welcomes government plans

New Industrial Fellowships support research on safer, more efficient and novel transport systems

Innovative technologies to improve transport on land, sea and in the air make up more than half the 19 new Royal Academy of Engineering Industrial Fellowships awarded today to mid-career academics and industrialists across the UK. The Industrial Fellowships aim to strengthen links between universities and industry and to encourage new collaborations. Placements range from six months to two years full- or part-time with the scheme covering the salary costs of each awardee up to a maximum of £50,000 per annum.

On the roads, new technologies being funded include novel power semiconductors for electric vehicles; a human-centric platform to help develop self-driving cars; and smart data compression techniques to enable faster sensors for automated vehicles.  

Researchers are helping to make rail travel safer and more resilient through more realistic simulation of how trains interact with railway infrastructure, and improving risk management systems to help reduce flooding. Next generation circuit breakers are being developed to make power supply more resilient, as well as new control and safety management systems suitable for the increasingly complex nature of the industry.

Aerospace projects will see engineering, geology and atmospheric science combined to reduce the impact of dust on jet engines and new flow measurement technologies will help to develop advanced aero-engines for aircraft of the future.

At sea, integrated mission management will enable autonomous vehicles to perform complex tasks at sea for longer, more reliably and at lower cost.

Among other challenges being addressed by the new Industrial Fellows are the reliability of legacy software systems; security threats posed by cyber-attacks; and how to turn waste plastics—including those that cannot be conventionally recycled—into new reusable plastic and clean low-sulphur fuels.

The 2020 awardees, industrial partners and projects are:

 

Dr Nicholas Bojdo, University of Manchester and Rolls-Royce plc
Mitigating damage to aero engines in dusty environments

Jet engines are optimised to breathe clean air but end up operating from dusty airports. The subsequent damage varies in nature from one region to the next. This project combines the disciplines of engineering, geology and atmospheric science to understand this variability and to inform damage mitigation solutions.

 

 

 

Stephanie Dawson, Hitachi Rail and University of Birmingham
Delivering a revolution in train testing with digital twin technology

This research project will develop a simulation to integrate Hitachi Rail’s train control software with the University of Birmingham’s Infrastructure Digital Twin using Hardware-In-The-Loop technology. This will allow train control software to be tested in a representative environment, realistically interacting the simulated train with the railway infrastructure.

 

 

 

Dr Andrea Diambra, University of Bristol and Gavin & Doherty Geosolution
CYCL-ON: introducing advanced cyclic soil modelling in offshore wind design

Offshore wind turbines are dynamically sensitive structures that must satisfy strict operability criteria under the critical cyclic storm loadings experienced during their design lifetime. Proper design and assessment of the turbine’s foundation properties is a key element in any design assessment. This project aims to improve the design procedures by including recent modelling developments that capture the full extent of the cyclic soil-foundation interaction mechanisms.

 

 

Dr Valentina Donzella, WMG, University of Warwick and ON Semiconductor
Smart data compression for automotive environmental perception sensors

Automated vehicles are on the verge of changing our lives. Sensing the environment requires the vehicles to deploy several sensors and each sensor collects a large quantity of data. This project investigates data-reduction and pre-processing techniques that might enable the fast decision-making process needed for safe motion of automated vehicles.

 

 

Dr Suzanne Embury, University of Manchester and Arm Holdings
Round-trip engineering of test suites for legacy software

Periodic reconstruction of software systems is necessary to control costs but is also risky. This project will create tools to capture organisational expertise from mission-critical legacy systems and package it in the form of reusable software test suites that can kick-start rapid and reliable reconstruction of those systems.

 

 

 

Dr Basel Halak, University of Southampton and ARM
Artificial Intelligence enhanced design for secure anti-tamper embedded devices

Compromised hardware products pose serious threats if used in critical infrastructure and military applications. The continuously evolving landscape of security threats calls for equally effective and adaptive defence mechanisms. This project will develop such a mechanism, using machine learning algorithms to rapidly detect malicious behaviours in an embedded system and intercede to stop a potential attack.

 

 

Dr Mike Jennings, Swansea University and Newport Wafer Fab Limited
Automotive qualified power semiconductor devices

Future automobile pistons will be based on power semiconductors that are ubiquitous within electric vehicle power electronic (PE) systems. This project aims to realise automotive-ready semiconductor components based on new materials such as gallium nitride and silicon carbide.

 

 

 

Dr Hongsin Kim, Birmingham Centre for Railway Research and Education, University of Birmingham and TÜV Rheinland Risktec Solutions Ltd
New paradigm for education in railway control and safety management

The rapid growth of digital technologies has highlighted the complex nature of the rail industry as never before. This project will provide effective teaching materials to support the next generation of industry leaders to fully understand the new requirements for risk/safety management in the digital railway.

 

Dr Gerald Morgan, Edenvale Young Associates and University of Bath
Modelling the effectiveness of natural flood risk management

This project aims to develop flood simulation model that can directly simulate modern, natural flood mitigation measures such as tree-planting and wetland regeneration. Using global-scale datasets and physically based approaches, the project will aim for broad applicability and robustness to climate change.

 

 

 

Dr Despina Moschou, University of Bath and Caura Ltd
Glucopatch: wearable devices for painless, user-driven glucose management

This fellowship will develop a second generation prototype from an existing device that includes a patch to continuously monitor glucose and lactate levels, currently used by professional athletes to improve their performance and training efficiency. It will explore the capabilities of the device for biomedical applications in healthcare.

 

 

Dr Hussam Muhamedsalih, University of Huddersfield and Paragraf Ltd
Robust measurement sensor for advanced manufacturing

The unique properties of two-dimensional materials such as graphene have many potential applications such as in semiconductors. This research will develop a novel sensor to rapidly measure the surfaces of these materials and the contaminants or impurities present, which can significantly affect the performance and prevent scale-up of the manufacturing process.

 

 

 

Dr Andrew Nichols, University of Sheffield and Network Rail
Whole-life costing and decision tools for rail drainage management

Railways use drainage systems to transport water away. When these become compromised, flooding can cause delays and endanger human life. This Fellowship will explore risk-based management approaches to support performance prediction and strategic financial and maintenance planning that will contribute to a more reliable and safer railway network for everybody.

 

 

 

Dr Daniel Paluszczyszyn, De Montfort University and HORIBA MIRA Ltd
Human centric platform for self-driving cars development, testing and validation

This collaboration aims to integrate De Montfort University’s Immersive Vehicle Virtual Reality Testbed simulator with HORIBA MIRA’s R&D testing ecosystem, including a connected and autonomous vehicle demonstrator. This setup will enable the study of a wide range of self-driving car concepts, helping to model participants’ behaviour in diverse, replicable, and close-to-reality scenarios.

 

 

 

Ben Pritchard, Thales and University of Southampton
Integrated Mission Management for Autonomous Systems

Navies and other maritime users expect autonomous vehicles to be able to perform ever more complex tasks for longer, further away, at lower cost, more reliably and with fewer people. Mr Pritchard’s research aims to understand how human supervisors can best interact with squads of mixed maritime autonomous vehicles to maximise human-system team performance.

 

 

 

Dr Leonid Shpanin, Sheffield Hallam University and BRUSH SWITCHGEAR LIMITED
Next-generation circuit breakers for enhanced performance of UK rail networks

A medium voltage direct current circuit breaker will be developed for DC rail applications. It will use an enhanced electromagnetic technique pioneered by Dr Shpanin to address the technical challenge of extinguishing large current faults or short circuits on UK railways, providing more reliable and resilient electric power delivery.

 

 

 

Dr Pengzhu Wang, Bridon International Ltd and Queen Mary University of London
Smart rope with sensing capability using multifunctional materials

Ropes are widely used in elevators, cranes, suspension bridges and marine vessels and unpredicted rope failures cause accidents. This collaborative project aims to develop high performance fibre ropes with built-in sensing capabilities that can help to eliminate safety concerns and allow wider use of ropes.

 

 

 

Dr Kit Windows-Yule, University of Birmingham and Recycling Technologies Ltd
Novel positron imaging and Euler-Lagrange modelling of plastic recycling systems

Plastic pollution is one of the foremost challenges of our age. Using cutting-edge numerical simulation and positron imaging techniques, this project will develop a novel recycling system to turn waste plastics—including those which cannot be conventionally recycled—into new plastic feedstocks and clean, low-sulphur fuels.

 

 

 

Dr Pavlos Zachos, Cranfield University and Rolls-Royce plc
Non-intrusive flow diagnostics in industrial testing for future aircraft configurations

Propulsion system integration for novel aircraft can benefit from the application of non-intrusive flow measurement technologies to understand complex aerodynamics. Dr Zachos’ research aims to transfer such measurement capability to industrial applications to support the development of advanced aero-engines for future aircraft architectures.

 

 

 

Dr Zhenyu Jason Zhang, University of Birmingham and Proctor and Gamble
SustainAble and Eco-Friendly (SAFE) consumer goods: a nano-formulation engineering approach

Building on expertise in soft matter engineering and tribology, this fellowship aims to help reduce water and energy use and increase the use of natural compounds for laundry, personal hygiene, household cleaning, discharging less waste in the form of surfactants and packaging materials.

 

 

 


Notes for Editors

  1. The Royal Academy of Engineering Industrial Fellowships scheme enables mid-career academics and industrialists to undertake a collaborative research project in either an industrial or academic environment, where one party would host the other. The scheme aims to strengthen the strategic relationship between industry and academia by providing an opportunity to establish or enhance collaborative research between the two parties.
  • The scheme is open to engineers from all disciplines
  • Awards can be held from six months to two years, full-time or part-time
  • The Academy will contribute up to a maximum of £50,000 (per-annum) towards the basic salary costs (excluding overheads) of the applicant, paid pro-rata against the amount of time to be spent at the host organisation. The total award is capped at £100,000 for awards that exceed one year in duration
     
  1. The Royal Academy of Engineering is harnessing the power of engineering to build a sustainable society and an inclusive economy that works for everyone. In collaboration with our Fellows and partners, we’re growing talent and developing skills for the future, driving innovation and building global partnerships, and influencing policy and engaging the public. Together we’re working to tackle the greatest challenges of our age.

Media enquiries to Pippa Cox, Communications Manager (email: Pippa.Cox@raeng.org.uk, ph: 020 7766 0740)

By |2020-11-05T10:45:46+00:00November 5th, 2020|Engineering News|Comments Off on New Industrial Fellowships support research on safer, more efficient and novel transport systems

Jonnie’s blade inspires next generation of engineers

Paralympic gold medallist Jonnie Peacock’s blade to become first exhibit in a new virtual museum, being developed by the Royal Academy of Engineering to help tackle engineer shortage in the UK

  • Paralympic gold-medallist Jonnie Peacock’s blade will become the first engineering exhibit in a new virtual museum accessible via QR Codes or ‘QRtefacts’

  • Visitors will be able to explore the ground-breaking engineering innovations that are tackling societal issues and shaping the everyday, including an exhibit on developing a Covid-19 vaccine

  • The Royal Academy of Engineering has announced plans to create the Museum of Engineering Innovation to celebrate often unsung engineering accomplishments and inspire engineers of the future in response to the worrying engineer shortage in the UK

  • The Museum, which will roll out in 2021, aims to challenge the narrow stereotype of engineering and encourage people from more diverse backgrounds to consider a career in the profession 

  • A preview collection of exhibits will be published on Google Arts & Culture onThis is Engineering Day which falls in Tomorrow’s Engineers Week

Plans to create a new virtual museum have been announced today by the Royal Academy of Engineering in an effort to address narrow perceptions of engineering that are contributing to a skills and diversity shortfall in the profession in the UK. Research from 2018 estimated that only 12%1 of the engineering workforce are female and just 9% are from BAME backgrounds.

Instead of being housed in a building, the exhibits in the virtual Museum of Engineering Innovation, when it rolls out in 2021, will be accessible via QR codes or ‘QRtefacts’.  Placed in accessible locations dotted around the UK, each QRtefact will signpost users to an individual exhibit within the online Museum.  Also accessed via Google Arts & Culture, the Museum will celebrate the often-unseen engineering that is all around us, shining a spotlight on the diverse engineers that are making a difference to our everyday lives and futures in a bid to inspire the next generation.

The first collection of exhibits will include the carbon fibre blade of reigning world champion and gold medallist, Jonnie Peacock. A QR code has been placed on the ‘Ferrari of running legs’, giving everyone (who can keep up with him) access to the virtual museum. Once scanned, or by visiting the Google Arts & Culture platform, visitors will be able to learn about the incredible engineering that went into making Jonnie’s blade, and how far the sporting world has come thanks to engineered high-performance prosthetics.

Jonnie Peacock comments on his blade becoming the virtual museum’s first QR-tefact:

“Whenever I wear my blade I get such a great response, particularly from children, able bodied and disabled, who think it’s really cool. I’d like them to know that I wouldn’t be where I am today and have this super cool prosthetic leg if it wasn’t for engineers and amazing feats of engineering, which is why I am supporting This is Engineering Day, to help demonstrate some of the many different ways engineering makes a difference and to inspire the engineers of the future.” 

The exhibits on ‘display’ at the museum will highlight the engineering that we often take for granted, but that has helped change, improve and in some instances, save lives. Exhibits will include Jonnie’s Blade along with the following2:

  • The Factory-in-a-box, developed by Professor Harris Makatsoris and his team of engineers at King’s College London, minimises the space and equipment needed for high volume vaccine manufacturing, making it possible to produce RNA-based vaccines, such as one of the vaccines being developed to tackle Covid-19, in any location and at a much faster rate than a typical vaccine manufacturing plant. 
  • The pBone, which is the first 3D printed plastic trombone.  The recyclable ABS plastic3 instrument, which weighs less than a kilogram and uses fewer resources than its brass cousin, is designed to encourage younger players who have difficulties with the weight and balance of a normal trombone  
  • Bricks made from recycled and breathable materials, also known as K-Briq, which will be used to create the 2021 Serpentine Pavilion
  • Motion capture digital technology, created by actor Andy Serkis’ company Imaginarium, that turned The Tempest’s Ariel into a 17ft high harpie in the Royal Shakespeare Company’s 2017 production
  • How the Singing in the Rain production, relaunching at Sadler’s Wells Theatre in 2021, made it rain on stage, whilst ensuring equipment stayed dry, avoiding technical problems
  • The 15-metre Arcadia Spider, which attracts thousands of party goers at Glastonbury Festival – an impressive, if unusual, example of engineering
  • A range of artwork shining a light on award winning feats of engineering by conceptual still life photographer Ted Humble-Smith
Jonnie Peacock’s running blade being scanned to access the Museum of Engineering Innovation

The announcement falls on This is Engineering Day (4th November), a national awareness day led by the Royal Academy of Engineering to address the narrow stereotype of engineering, celebrate the varied and vital roles that engineers play, and encourage more young people to consider a career in the profession. The day is part of Tomorrow’s Engineers Week, a week of activities designed to provide inspiring and exciting opportunities for young people to experience the world of engineering.

On This is Engineering Day the Academy will also be calling on organisations and brands that rely on engineers and engineering to nominate engineering innovations that are making a difference to exhibit in the Museum in 2021.

Dr Hayaatun Sillem CBE, Chief Executive of the Royal Academy of Engineering, comments:

“Engineers play a profoundly important role in shaping the world around us, however research3 reveals that over three quarters (76%) of young people aged 11-19 and 73% of parents do not know a lot about what those working in engineering actually do. This is an issue that affects all of us because without a skilled and diverse engineering workforce we will not be able to power a sustainable economic recovery in the UK, or tackle some of our biggest global challenges. 

That’s why today, on This is Engineering Day, we are announcing plans to create the virtual Museum of Engineering Innovation. This is Engineering Day gives us an opportunity to bring untold stories to life in a way that shows the surprising and inspiring role that engineers play as hidden enablers of progress. Engineering is a fantastic career if you want to make a difference, improve people’s lives and shape the future, and through our Museum of Engineering Innovation we want to inspire many more people from all parts of society to become future engineers.”

Amit Sood, Director of Google Arts & Culture, comments:

“If you were asked what links a West End musical, an Olympic athlete and the Mary Rose ship, what would the answer be? These are just a few examples of the stories that the Royal Academy of Engineering are bringing to life that demonstrate the importance of engineering in our daily lives. We are delighted to share a selection of online exhibits on Google Arts & Culture to help celebrate This Is Engineering Day and we are looking forward to building on this initial launch for audiences around the world to get inspired by engineering.”

This is Engineering Day is part of the This is Engineering campaign, led by the Royal Academy of Engineering to give more young people, from all backgrounds, the opportunity to take up engineering careers. More information on the campaign can be found at www.ThisisEngineering.org.uk, @ThisisEng on Twitter and @ThisisEngineering on Instagram. #BeTheDifference #ThisIsEngineering

Notes to editors

  1. Research carried out by EngineeringUK. Data from the 2018 State of Engineering Report
  2. Exhibits featured in the first collection can be accessed at https://artsandculture.google.com/partner/museum-of-engineering-innovation
  3. Research carried out by EngineeringUK. Data from the 2019 Engineering Brand Monitor captured in Jan – Feb 2019, based on a sample of 2,514 pupils aged 7-19, 1,023 educators, and 1,810 members of the public

About Jonnie Peacock

Jonnie is the Double Paralympic, World & European T44 100m Champion. He sensationally won his first Paralympic title at the London 2012 Games during one of the best summers in British Athletics history. He then successfully defended his title at the Rio 2016 Paralympics. Jonnie is already an inspiration to many young people and is passionate about building the profile of disability sport globally. He has vowed to take part in as many Paralympics as he possibly can, with the hope of winning more medals in the process.

About This is Engineering

This is Engineering is a campaign to raise awareness of the breadth of careers in engineering and help address the significant engineering skills and diversity shortfall that is holding back growth and productivity across the UK economy. The campaign aims to give more young people, from the broadest possible backgrounds, the opportunity to take up an exciting, engaging, rewarding and in demand career.

This is Engineering is led by the Royal Academy of Engineering, in collaboration with EngineeringUK. The campaign has been made possible thanks to the generous support of the Fellows of the Royal Academy of Engineering and our corporate partners. More information about the campaign is available at www.thisisengineering.org.uk and @ThisIsEng on Twitter

Strategic partner

EngineeringUK

Founding Principal partners

BAE Systems

National Grid

Principal partners

Amazon

Anglo American

BP

Centrica

Rolls-Royce

Shell UK

Major partners

Facebook

Google Arts & Culture

Sponsors

MBDA

Mott MacDonald

Teledyne e2v

WSP

Principal university partners

University of Oxford

Major university partners

Anglia Ruskin University

Aston University

University partners

Kings College London

Manchester Metropolitan University

University of Southampton

University of Glasgow

About Tomorrow’s Engineers Week

Tomorrow’s Engineers Week (#TEWeek20) takes place from 2-6 November 2020 and highlights to young people that engineering is a creative, problem solving, exciting career that improves the world around us. Tomorrow’s Engineers Week is led by EngineeringUK. To find out how to get involved, visit www.tomorrowsengineers.org.uk/teweek

About the Royal Academy of Engineering

The Royal Academy of Engineering is harnessing the power of engineering to build a sustainable society and an inclusive economy that works for everyone.

In collaboration with our Fellows and partners, we’re growing talent and developing skills for the future, driving innovation and building global partnerships, and influencing policy and engaging the public.

 Together we’re working to tackle the greatest challenges of our age.

About EngineeringUK

EngineeringUK is a not-for-profit organisation, which works in partnership with the engineering community to inspire tomorrow’s engineers and increase the number and diversity of young people choosing academic and vocational pathways into engineering. EngineeringUK leads engagement programmes The Big Bang, Robotics Challenge and Energy Quest, helps schools bring STEM to life through real-world engineering via Neon, creates inspiring engineering careers resources and campaigns through Tomorrow’s Engineers and produces a body of research including the flagship State of Engineering report.www.engineeringuk.com

About Google Arts & Culture

Google Arts & Culture puts the collections of more than 2,000 museums at your fingertips. It’s an immersive way to explore art, history and the wonders of the world, from Van Gogh’s bedroom paintings to the women’s rights movement and the Taj Mahal. The Google Arts & Culture app is free and available online for iOS and Android. The team has been an innovation partner for cultural institutions since 2011. Google Arts & Culture develops technologies that help preserve and share culture and allow curators to create engaging exhibitions online and offline.

By |2020-11-04T00:01:00+00:00November 4th, 2020|Engineering News|Comments Off on Jonnie’s blade inspires next generation of engineers

Government investment too low to achieve net zero recovery, say engineers

  • New report from the National Engineering Policy Centre calls for greater investment in net-zero capacity and digital transformation, and national workforce planning strategy to increase technical capability

There is a large gap between government funding commitments and the true scale of changes required for a net-zero economic recovery from COVID-19, according to a paper published today by the National Engineering Policy Centre, which represents 43 UK engineering organisations with a combined membership of nearly half a million engineers. With one year until COP 26 the UK has a responsibility to be a global leader for rapid carbon emissions reduction. The paper calls on the government to step up the level of investment it is prepared to make in clean growth to match that of other ambitious nations like Germany and the Republic of Ireland, to maintain international competitiveness, and build on the UK’s strengths and capabilities in clean technologies.

Read ‘Beyond COVID-19: laying the foundations for a net-zero recovery’ here

Urgent action is needed to build net-zero capacity, says the paper, and policy decisions that can rapidly mobilise entire industries must be taken if the UK is to meet its carbon emissions target of net zero by 2050. In tackling the current employment and economic crises caused by the pandemic, the government must not lose sight of broader objectives such as net zero, resilience, international competitiveness and the need to create a more equal society. The paper sets out five foundations for government to deliver a net zero recovery.

Read a summary of the paper here

The UK has a chance to make the best use of its existing assets and to develop more flexible and efficient infrastructure systems for the future, says the paper. It recommends that recovery funds for carbon-intensive industries should require them to commit to ambitious but achievable targets for reducing greenhouse gas emissions. These include engineering industries such as aviation, rail and energy-intensive manufacturing such as steel production and chemical processing. Cumulative, connected change is required across different policy areas and economic sectors to deliver net-zero, and government should consider the technologies that will be needed and how people’s jobs and lives will be impacted as a result.

The five foundations in the paper are:

  • Government must ensure that recovery packages work together as a whole to pivot the UK towards a net-zero economy.
  • Government spending on new infrastructure and public buildings must avoid the trap of high carbon construction methods and lay the foundations for a future net-zero infrastructure system including minimising the need for future retrofitting, by basing spending choices on outcomes and including whole-life carbon evaluation.
  • Government should drive digital transformation as an essential enabler of net-zero and resilience.
  • Government must increase the UK’s technical capability to deliver net-zero by creating a national workforce planning strategy and implementing proactive policies on diversity and inclusion in employment and training that will help reverse the impact of COVID-19 on employment opportunities for women and people from Black, Asian and minority ethnic backgrounds.
  • Government should deploy a cross-sectoral systems approach to policymaking that accounts for the impact that transforming one part of the economy or national infrastructure will have on the others.

Dervilla Mitchell CBE FREng, UKIMEA chair at Arup and a chair of the National Engineering Policy Centre Net Zero Working Group, says:

“We must guard against the possibility that, as economies around the world recover from the impacts of the pandemic, plans for a low-carbon recovery unravel, and we lock the country into high-emissions infrastructure and systems that simply return us to past norms.

“Investing in low-carbon technology and practices now will create jobs and pay dividends for the economy and the UK’s net-zero emissions target.

“Real progress on reducing carbon emissions will need to be built in the short-term, maintained over the long term, be sustainable over successive governments, and able to withstand disruptive events in future.”

Notes for Editors

The National Engineering Policy Centre

We are a unified voice for 43 professional engineering organisations, representing 450,000 engineers, a partnership led by the Royal Academy of Engineering.

We give policymakers a single route to advice from across the engineering profession.

We inform and respond to policy issues of national importance, for the benefit of society.

The Royal Academy of Engineering is harnessing the power of engineering to build a sustainable society and an inclusive economy that works for everyone.

In collaboration with our Fellows and partners, we’re growing talent and developing skills for the future, driving innovation and building global partnerships, and influencing policy and engaging the public.

Together we’re working to tackle the greatest challenges of our age.

For more information please contact: Victoria Runcie at the Royal Academy of Engineering Tel. 0207 766 0620; email: victoria.runcie@raeng.org.uk

By |2020-11-02T00:01:17+00:00November 2nd, 2020|Engineering News|Comments Off on Government investment too low to achieve net zero recovery, say engineers

New online and in-classroom student activities launched for This is Engineering Day

  • Schools can register now to ask engineers questions on Wednesday 4 November

  • This is Engineering: Entertainment activity pack now available for schools

Students are invited to a live Q&A event to ask engineers about how the technology they develop is changing our lives on This is Engineering Day, Wednesday 4 November 2020.

With a theme of #BeTheDifferenceThis is Engineering Day will celebrate the engineering that shapes our world for the better, whether that’s by making our day to day lives easier or tackling some of our biggest global challenges.

The Royal Academy of Engineering will host online Q&A sessions, where two engineers will answer students’ questions live.

Schools are invited to register for one of the five sessions here

  • 9.15am – How technology is changing the way we communicate
  • 10.15am – How to respond to a global health crisis
  • 11.15am – How to get into engineering
  • 1.45pm – Engineering sport
  • 2.45pm- How to engineer a sustainable world

This is Engineering Day is part of the This is Engineering campaign, led by the Royal Academy of Engineering, which aims to give more young people from all backgrounds an opportunity to consider engineering careers.

Students can also explore the essential role that engineers play in the entertainment industry with a new STEM (science, technology, engineering and maths) activity pack. This is Engineering: Entertainment contains intriguing activities and challenges inspired by engineers featured in the This is Engineering campaign. Students can get involved by tracking sporting data, exploring the ‘4th dimension’, creating light displays, investigating synthetic beats and producing a scene from a horror film. 

Most activities can be done in the classroom or at home without extra equipment.

Download the activity pack here

Some 17,500 individual student packs will be distributed via almost 1,000 schools across the UK, each containing the materials needed to complete all the different challenges. Teachers can register to join the Academy’s Connecting STEM Teachers programme to receive training and the complete education resources.

Find out more about the Connecting STEM Teachers programme here

Notes for Editors

The Royal Academy of Engineering is harnessing the power of engineering to build a sustainable society and an inclusive economy that works for everyone.

In collaboration with our Fellows and partners, we’re growing talent and developing skills for the future, driving innovation and building global partnerships, and influencing policy and engaging the public.

Together we’re working to tackle the greatest challenges of our age.

What we do

TALENT & DIVERSITY

We’re growing talent by training, supporting, mentoring and funding the most talented and creative researchers, innovators and leaders from across the engineering profession.

We’re developing skills for the future by identifying the challenges of an ever-changing world and developing the skills and approaches we need to build a resilient and diverse engineering profession.

INNOVATION

We’re driving innovation by investing in some of the country’s most creative and exciting engineering ideas and businesses.

We’re building global partnerships that bring the world’s best engineers from industry, entrepreneurship and academia together to collaborate on creative innovations that address the greatest global challenges of our age.

POLICY & ENGAGEMENT

We’re influencing policy through the National Engineering Policy Centre – providing independent expert support to policymakers on issues of importance.

We’re engaging the public by opening their eyes to the wonders of engineering and inspiring young people to become the next generation of engineers.

For more information please contact: Victoria Runcie at the Royal Academy of Engineering Tel. 0207 766 0620; email: victoria.runcie@raeng.org.uk

By |2020-10-21T16:07:46+00:00October 21st, 2020|Engineering News|Comments Off on New online and in-classroom student activities launched for This is Engineering Day

Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part II


Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part II | Johnson Matthey Technology Review















Johnson Matthey Technol. Rev., 2021, 65, (1), 23

doi:10.1595/205651320×15864407040223

Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part II

From the University of Cardiff to retirement interests and scientific legacy

  • John Burgess
  • Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK
  • Martyn V. Twigg*
  • Twigg Scientific & Technical Ltd, Caxton, Cambridge CB23 3PQ, UK
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Article Synopsis

The second part of this commemoration covers the final stage of Robert Gillard’s career as Professor of Inorganic Chemistry at Cardiff University and his time in retirement. At Cardiff he built on earlier work while extending his scientific interests still further into mineralogical and archaeological chemistry, and even into forensic dentistry. Coordination chemistry research continued and included the polysulfide S5 chain as a bidentate ligand in the all-inorganic cyclic PtS5 unit and the rhodium(III) complex [Rh(S5)3]3–. His penchant for discussion led him into several controversies, particularly over his ‘covalent hydration’ hypothesis of coordinated nitrogen-carbon double bonds in metal complexes which included those with platinum and 2,2’-bipyridine. He travelled widely attending international conferences and giving lectures. Research collaborations continued throughout his time at Cardiff and in particular he had many strong links with Portugal, both with colleagues there and as supervisor of Portuguese higher degree students at Cardiff. His years in retirement were spent in finalising his research legacy, in continuing to read historical literature, both chemical and otherwise, and in following his musical interests that had included many years singing in the Cwmbach Male Voice Choir

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By |2020-10-20T15:47:27+00:00October 20th, 2020|Weld Engineering Services|Comments Off on Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part II

Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part I


Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part I | Johnson Matthey Technology Review















Johnson Matthey Technol. Rev., 2021, 65, (1), 4

doi:10.1595/205651320×15864407040160

Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part I

From early life to the University of Kent at Canterbury

  • John Burgess
  • Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK
  • Martyn V. Twigg*
  • Twigg Scientific & Technical Ltd, Caxton, Cambridge CB23 3PQ, UK
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Article Synopsis

This first part of a two-part commemoration of the life and work of Robert D. Gillard begins with a biographical outline which provides a context for his chemical achievements. He was awarded a State Scholarship and after his National Service in the Royal Air Force he went up to St Edmund Hall, Oxford, to read Chemistry. There follows a chronological account of his career in Chemistry starting with his undergraduate days in Oxford, where a Part II project with Dr Harry Irving on alkaline earth and cobalt complexes proved seminal. His PhD research at Imperial College, London in the Geoffrey Wilkinson group broadened his experience into the then poorly developed chemistry of rhodium and other platinum group metal complexes. Gillard next went to Sheffield University as a Lecturer where he developed independent research while continuing to work on earlier topics. There followed a move to Canterbury as a Reader at the University of Kent. In his particularly productive seven years there with a large research group he widened his experience further, expanding his interests in such areas as the optical properties of transition metal complexes, considering biological and medical relevance, and increasing the range of metals and ligands he investigated. His subsequent time at Cardiff and then into retirement will be covered in the second part of this commemoration.

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By |2020-10-20T15:02:14+00:00October 20th, 2020|Weld Engineering Services|Comments Off on Professor Robert D. Gillard: Transition Metal Chemist 1936–2013: Part I

Biocatalytic Reduction of Activated Cinnamic Acid Derivatives

Johnson Matthey Technol. Rev., 2020, 64, (4), 529

1. Introduction

The use of enzymes for the asymmetric reduction of activated C=C double bonds can be a viable and straightforward alternative to asymmetric hydrogenation. Traditionally, whole cell microorganisms were used for this purpose but a recent increase in the number of isolated and characterised ENEs means that recombinantly-expressed enzyme preparations are now generally favoured over whole cells, as a number of recent publications demonstrate (110).

Double bond ‘activation’ to facilitate ENEs mediated reduction can be achieved in many cases by alpha substituted functional groups including aldehydes, ketones or nitro moieties. Carboxylate derivatives (such as esters, lactones and anhydrides) can also act as activating groups but their ability to sufficiently activate the C=C bond in the absence of other groups is less evident (11, 12). The traditional approach in these cases is to turn to chemocatalytic hydrogenation (see (1315) for reviews focused on industrial applications). Herein we describe a new approach to activate α,β-unsaturated carboxylic acids for the reduction with ENEs using a substrate engineering approach.

2. Experimental

2.1 General

All reagents and solvents were purchased from Sigma-Aldrich and Alfa Aesar, Thermo Fisher Scientific. They were of the highest available purity and were used without further purification. 1H nuclear magnetic resonance (NMR) spectra were recorded using a Bruker 400 MHz Avance III HD equipped with SMART probe (Bruker Corporation, USA) where spectra are referenced to deuterated chloroform (CDCl3) 7.26 ppm, shifts are recorded in parts per million and J values in hertz. The NMR results can be found in the Supplementary Information.

2.2 Enzyme Preparations

Genes coding for Johnson Matthey, ENEs (ENE-101, ENE-102, ENE-103, ENE-104, ENE-105, *ENE-69 and GDH-101) were ordered codon-optimised from GeneArt (Thermo Fisher Scientific) and cloned into T5 vector pJEx401 (ATUM). Enzymes were expressed recombinantly in Escherichia coli BL21 in both shake flasks and fed batch fermentations, whereby induction was carried out with isopropyl β-D thiogalactopyranoside (IPTG) at 30°C. Harvested biomass was resuspended in 100 mM potassium phosphate buffer (pH 7) and cells were broken up either by sonication or homogenisation. The so-obtained cell lysate was clarified by centrifugation and filtrated prior to lyophilisation. Protein expression was assessed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and chromatographic activity assays.

Enzymes ERED-103, ERED-110, ERED-112, ERED-207, ERED-P1-A04, ERED-P1-E04 and ERED-P1-H09 were purchased from Codexis.

2.3 2,2,2-Trifluoroethyl Cinnamate (3a) and 3-Phenyl-Acrylic Acid 2,2,2-Trifluoro-1-Trifluoromethyl-Ethyl Ester (5a)

Cinnamic acid 1a (5 g, 33.75 mmol) and oxalyl chloride (2.85 ml, 33.75 mmol) in dichloromethane (5 ml) were stirred at 25°C for 2 h before adding the fluorinated alcohol-trifluoro ethanol for 3a (2.47 ml, 33.75 mmol) and 1,1,1,3,3,3-hexafluoropropan-2-ol for 5a (3.50 ml, 33.75 mmol). The reaction was then stirred at room temperature overnight before being quenched by addition of saturated aqueous NaHCO3 (20 ml) and extracted with dichloromethane (2 × 20 ml), dried over MgSO4, filtered and concentrated under reduced pressure to afford the corresponding fluorinated esters 3a and 5a in quantitative yield.

2.4 3-Phenyl-Acrylic Acid 2,2,3,3,4,4,4-Heptafluoro-Butyl Ester (6a) and (Perfluorophenyl)Methyl Cinnamate (7a)

Cinnamoyl chloride (0.75 g, 4.50 mmol) and the corresponding fluorinated alcohols – 2,2,3,3,4,4,4-heptafluorobutan-1-ol for 6a (0.98 g, 4.50 mmol) and pentafluroro benzyl alcohol for 7a (0.89 g, 4.50 mmol) – in dichloromethane (2.5 ml) were stirred at room temperature overnight. The reaction was then quenched by addition of saturated aqueous NaHCO3 (20 ml) and extracted with dichloromethane (2 × 20 ml), dried over MgSO4, filtered and concentrated under reduced pressure to afford the corresponding fluorinated esters 6a and 7a in 95% to 99% yield.

2.5 1-Cinnamoylpyrrolidin-2-one (9a)

Cinnamoyl chloride (5 g, 30.01 mmol), pyrrolidinone (2.3 ml, 36.01 mmol) and triethylamine (13 ml, 90.03 mmol) in dichloromethane (50 ml) were stirred at room temperature overnight. The reaction was quenched by addition of water (20 ml), the organic layer was separated and washed with saturated aqueous NaCl (20 ml), dried over MgSO4, filtered and concentrated under reduced pressure to afford 9a in 81% yield.

2.6 3-Cinnamoyloxazolidin-2-one (8a)

Cinnamic acid 1a (5 g, 33.56 mmol) and oxalyl chloride (2.85 ml, 33.56 mmol) in dichloromethane (5 ml) were stirred at room temperature overnight before removing the solvent under reduced pressure. The reaction crude was dissolved in anhydrous tetrahydrofuran (THF) (20 ml) and n-butyllithium (1.6 M in hexane, 21 ml, 33.56 mmol, one equivalent) was added dropwise over 30 min. The cinnamoyl chloride solution was then added dropwise to a solution of oxazolidinone (2.92 g, 33.56 mmol) in anhydrous THF (100 ml) at 0°C before stirring at room temperature overnight. The reaction was quenched with water (50 ml), extracted with ethyl acetate (EtOAc) (2 × 100 ml), washed with saturated aqueous NaHCO3 (20 ml) and saturated aqueous NaCl (20 ml). The solvent was removed under reduced pressure and the solid was recrystallised from a 1:1 mixture EtOAc:heptane (20 ml). The solid was filtered and washed with hexane (10 ml) to give crystals of 8a in 80% yield.

2.7 (E)-1-(2-Methyl-3-Phenylacryloyl)Pyrrolidin-2-one (10a) and (E)-1-(2,3-Diphenylacryloyl)Pyrrolidin-2-one (11a)

(E)-2-methyl-3-phenylacrylic acid (5 g, 30.86 mmol) was converted to the corresponding acid chloride by addition of oxalyl chloride (1.4 ml, 30.86 mmol) in dichloromethane (5 ml). The reaction was stirred at room temperature for 3 h. Pyrrolidinone (2.82 ml, 37.03 mmol) and triethylamine (13 ml, 92.58 mmol) were added before stirring the reaction overnight. The reaction was quenched by addition of water (20 ml) and saturated aqueous NaCl (20 ml). The solvent was removed under reduced pressure and the solid was dissolved in EtOAc and treated with activated charcoal (1 g), filtered through Celite® and concentrated. The solid was recrystallised from heptane (10 ml) to give 10a in 55% yield.

Following an identical procedure, 11a was synthesised in 53% yield from (E)-2,3-diphenylacrylic acid (10 g, 44.64 mmol).

2.8 Small Scale Screening Reactions

Substrates 1a–9a (0.025 mmol) and enzymes ENE-101, ENE-102, ENE-103, ENE-104, ENE-105 or *ENE-69 (2.5 mg), were added to reaction vials containing 500 μl of aqueous media at pH 7 (250 mM potassium phosphate buffer pH 7, 1.1 mM NAD(P)+, 100 mM D-glucose, 10 U ml−1 GDH-101) to give a final concentration of substrate of 50 mM. The vials were shaken at 400 rpm, 30°C for 18 h. For high-performance liquid chromatography (HPLC) analysis, the reactions were quenched with acetonitrile (MeCN) (1 ml), vortexed, centrifuged and aliquoted. For gas chromatography (GC) analysis, samples were extracted with EtOAc (2 × 0.5 ml), dried over MgSO4 and analysed directly. For NMR analysis, the reactions were extracted with CDCl3 and analysed directly.

2.9 Preparative Scale Screening Reactions

Reactions were scaled up using three-neck round bottom flask equipped with stir bar and pH titrator (10 M NaOH). To the flask was weighed 100–500 mg substrate (40–100 mM final concentration) and 5 mg ml−1 enzyme which was suspended in aqueous media at pH 7 (250 mM potassium phosphate buffer pH 7, 1.1 mM NAD(P)+, 100–200 mM D-glucose (two equivalent), 10 U ml−1 GDH-101) the reactions were stirred at 30°C, 400 rpm for 18 h.

2.10 Analytical Methods

HPLC analysis of conversion was conducted on an 1260 Infinity II LC system (Agilent, USA) using a C18 SunFire Column (Waters Corporation, USA, 150 × 4.6 mm, 3.5 μm) with an isocratic method (MeCN:Water, 30:70 + 0.1% trifluoroacetic acid) and a flow rate of 1 ml min−1.

Chiral HPLC analysis was performed on a Varian ProStar series (Agilent) with a CHIRALCEL® OD-H column (Chiral Technologies, USA, 250 × 4.6 mm, 5 μm) with an isocratic method A (heptane:isopropyl alcohol (IPA), 88:12) and a flow rate of 1 ml min−1 or isocratic method B (heptane:IPA, 98:2).

GC analysis of conversion was performed on a Varian CP-3800 (Agilent) using γ-DEX™ 225 capillary column (Sigma-Aldrich, 30 m × 0.25 mm × 0.25 μm) and using helium as carrier gas. Percentage conversion was measured by integration of the product peak in the GC (uncorrected area under curve (AUC)), values below 100% indicate that unreacted starting material was detected. No side products were detected in any of the reported reactions. GC program parameters: injector 250°C, flame ionization detector (FID) 250°C, 80°C for 3 min then 5°C min−1 up to 160°C, hold 1 min (total time 20 min), constant flow 5 ml min−1.

3. Results and Discussion

It has been found that a particular ENE in Johnson Matthey’s collection, a homologue from the tobacco ENE reductase fold (16), ENE-105, was capable of reducing methyl ester 2a (Figure 1), albeit in a very low yield of 3% (Entry 2, Table I). By comparison, cinnamic acid 1a was a poor substrate and showed no conversion to the reduced product 1b at pH 7.0 (Entry 1, Table I). The pKa of cinnamic acid 1a is 4.4 and therefore, at pH 7.0, the carboxylic acid should be deprotonated affecting its ability to bind to the enzyme active site. This observation is in line with other literature examples where carboxylates were found to be poor activating groups (17). Encouraged by this initial result, we turned our efforts towards the use of more activated esters. It was envisaged that converting the alkyl chain in the ester moiety to a more EWG could lead to an increase in double bond activation. A similar approach has been reported previously by BASF SE for the lipase-catalysed kinetic resolution of racemic amines and alcohols, where the choice of acylating agent proved critical (18). We chose trifluoroethyl ester 3a as a starting point which was reduced by ENE-105 and *ENE-69 in 6% and 12% conversion respectively (Entry 3, Table I) suggesting that the addition of an EWG had a positive activating-effect on the reduction. To consolidate this theory, ethyl ester 4a was tested with the novel ENEs; only a trace of reduction was observed <0.5% (Entry 4, Table I).

Fig. 1

Reduction of cinnamic acid and cinnamoyl esters. [a] = 1–7a (50 mM concentration), ENE-105 or ENE-69 (5 mg ml−1), 500 μl buffer (250 mM KPi, pH 7, 1.1 mM NAD(P)+, 100 mM D-glucose, 10 U ml−1 GDH-101), 400 rpm, 30°C, 18 h

Reduction of cinnamic acid and cinnamoyl esters. [a] = 1–7a (50 mM concentration), ENE-105 or ENE-69 (5 mg ml−1), 500 μl buffer (250 mM KPi, pH 7, 1.1 mM NAD(P)+, 100 mM D-glucose, 10 U ml−1 GDH-101), 400 rpm, 30°C, 18 h

Table I

Reduction of Cinnamoyl Esters at 50 mM Substrate Concentration, pH 7, 30°C, 18 h

Entry Substrate Conversion, %a
ENE-105 *ENE-69
1b 1a 0 0
2 2a 3 1
3 3a 6 12
4 4a <0.5 <0.5
5c 5a 0 0
6d 6a <0.5 <0.5
7d 7a 0 0

Other EWGs such as hexafluoroethyl in compound 5a, heptafluorobutyl in 6a and pentafluorobenzyl in 7a could also activate the double bond in the same way, so 5a, 6a and 7a were prepared by reacting cinnamoyl chloride with the corresponding fluorinated alcohols and these substrates were subsequently tested with the ENEs. Hexafluoro 5a was not reduced by ENE-105 or *ENE-69 (Entry 5, Table I), instead, a significant amount of hydrolysis product (cinnamic acid 1a, 10%) was observed. Heptafluorobutyl 6a and pentafluoro 7a were poor activating groups with 6a showing only a trace amount of product 6b (Entry 6, Table I) and 7a giving no conversion (Entry 7, Table I).

With only limited success with the fluorinated activating groups, our efforts turned towards cyclic imides since activated substrates 8a and 9a have been shown to be highly activated towards Michael addition reactions (19, 20, 21) (Figure 2). Compounds 8a and 9a were synthesised and tested with enzymes ENE-105 and *ENE-69. Pleasingly, oxazolidinone 8a was successfully reduced by both ENEs (51% and 39% conversion to 8b, Entry 1, Table II) and pyrrolidinone 9a was reduced to 9b in >95% conversion (Entry 2, Table II), proving to be an excellent activating group. The 1H NMR shift of the alkene proton alpha to the carbonyl for pyrrolidinone 9a is shifted down field (7.92 ppm) compared to cinnamic acid 1a (6.46 ppm), therefore supporting the electron-withdrawing nature of the activating group.

Fig. 2

Cinnamoyl cyclic imide derivatives. [a] = 8a–9a (50 mM concentration), ENE-105 or ENE-69 (5 mg ml−1), 500 μl buffer (250 mM KPi, pH 7, 1.1 mM NAD(P)+, 100 mM D-glucose, 10 U ml−1 GDH-101), 400 rpm, 30°C, 18 h

Cinnamoyl cyclic imide derivatives. [a] = 8a–9a (50 mM concentration), ENE-105 or ENE-69 (5 mg ml−1), 500 μl buffer (250 mM KPi, pH 7, 1.1 mM NAD(P)+, 100 mM D-glucose, 10 U ml−1 GDH-101), 400 rpm, 30°C, 18 h

Table II

Reduction of Cinnamoyl Cyclic Imide Derivatives at 50 mM Substrate Concentration, pH 7, 30°C, 18 h

Entry Substrate Conversion, %
ENE-105 *ENE-69
1a 8a 51 39
2b 9a >95 >95

The enzymes were then tested for their ability to reduce α-substituted cinnamic acid derivatives such as α-methyl 10a and α-phenyl 11a (Figure 3). Encouragingly, the tri-substituted double bond in 10a was reduced to 10b in >95% conversion by 1H NMR analysis (Entry 2, Table III). However, bulkier substrate 11a, was not tolerated so well on an analytical scale due to solubility issues causing mass-transfer limitations (Entry 3, Table III). The reaction was repeated on a larger scale with stirring (Entry 4, Table III) and >95% conversion was achieved. 10b and 11b were obtained as racemic mixtures.

Fig. 3

Reduction of α-substituted cinnamoyl pyrrolidinones. [a] = 9a–11a (40–100 mM concentration), ENE-105 or ENE-69 (5 mg ml−1), buffer (250 mM KPi, pH 7, 1.1 mM NAD(P)+, two equivalent D-glucose, 10 U ml−1 GDH-101), 400 rpm, 30°C, 18 h

Reduction of α-substituted cinnamoyl pyrrolidinones. [a] = 9a–11a (40–100 mM concentration), ENE-105 or ENE-69 (5 mg ml−1), buffer (250 mM KPi, pH 7, 1.1 mM NAD(P)+, two equivalent D-glucose, 10 U ml−1 GDH-101), 400 rpm, 30°C, 18 h

Table III

Reduction of α-Substituted Cinnamoyl Pyrrolidinones at 50 mM Substrate Concentration, pH 7, 30°C, 18 h

Entry Substrate Conversion, %a
ENE-105 *ENE-69
1 9a >95 >95
2 10a >95 >95
3 11a 24 2
9b 11a >95

With a successful activating group found, the reaction was repeated on a preparative scale to test reproducibility and scalability (Table IV). Pyrrolidinone 9a was successfully reduced using enzyme ENE-105 at 130 mg scale with the desired product 9b being obtained in 95% conversion by 1H NMR (Entry 1, Table IV). 72% conversion to 10b was achieved after 20 h (Entry 3, Table IV) on the reduction of pyrrolidinone 10a at 500 mg scale.

Table IV

Reduction of Cinnamoyl Pyrrolidinones by ENE-105 at pH 7b and 30°C

Entry Substrate Scale, mg Concentration, mM Time, h Conversion, %a
1 9a 130 40 16 >95
2 10a 500 100 4 33
3 10a 500 100 20 72

Having found enzymes in Johnson Matthey’s collection that could successfully reduce masked carboxylic acids, other commercially available enzymes were tested as a comparison on the reduction of 10a (Table V). Six enzymes from Johnson Matthey collection (Entries 3 to 6, Table V) and seven enzymes purchased from Codexis (Entries 7 to 13, Table V) were compared with ENE-105 and ENE-69* (Entries 1 and 2, Table V). It was found that, despite the extra activation of the C=C double bond, none of the tested enzymes could reduce cinnamic acid derivative 10a, highlighting the unique ability of ENE-105 and *ENE-69 within the focused library (13 enzymes) screened.

Table V

Reduction of Cinnamoyl Pyrrolidinone 10a at 50 mM Substrate Concentration, pH 7, 30°C, 18 h

Entry Enzyme Conversion, %a
1 ENE-105 >95
2 *ENE-69 >95
3 ENE-101 <0.5
4 ENE-102 1
5 ENE-103 0
6 ENE-104 0
7 ERED-103 0
8 ERED-110 0.5
9 ERED-112 0
10 ERED-207 <0.5
11 ERED-P1-A04 1
12 ERED-P1-E04 0
13 ERED-P1-H09 0

In summary, we have shown that cinnamic acid derivatives activated as fluorinated esters or as cyclic imides can be reduced using Johnson Matthey enzymes ENE-105 or *ENE-69. The concept of ‘substrate engineering’ as opposed to ‘enzyme engineering’, offers a complimentary and faster approach to developing a bioprocess, making difficult transformations possible. The reduced products can be subsequently converted to the parent carboxylic acids by LiOH hydrolysis (22, 23) and the potential re-use of these activating groups will be investigated in the future. It is envisaged that the work will lead to further examples of activated acids or esters being reduced by ENEs.

4. Conclusions

The biocatalysed reduction of the double bond of cinnamic acid derivatives is strongly influenced by the nature of the EWG. While no conversion was observed on the biocatalysed reduction of cinnamic acid 1a, an enzyme in Johnson Matthey’s collection, ENE-105, was capable of reducing methyl ester derivative 2a in low conversion. By replacing the alkyl chain in the ester moiety by a more EWG, such as fluorinated alkanes, and in the presence of enzymes ENE-105 and *ENE-69, we were able to significantly increase conversion to the reduced product. Furthermore, other electronegative derivatives such as cyclic imides proved to be even better activating groups, allowing the reduction of challenging substituted double bonds such as substrates 10a and 11a.

In summary, by ‘masking’ the carboxylic acid moiety into a fluorinated alkyl ester or a cyclic imide, following a straightforward synthetic procedure, and in combination with the right enzyme, it was possible to biocatalytically reduce the conjugated double bond of cinnamic acid and substituted derivatives.

The Authors


Samantha Staniland graduated from The University of Manchester, UK, in 2011 with an MChem in Chemistry with Industrial Experience, while carrying out her industrial placement at Pfizer, UK, in Medicinal Chemistry. In 2011–2015, Sam did a PhD in the groups of Professor Jonathan Clayden and Professor Nicholas Turner on the biocatalytic asymmetric synthesis of atropisomers. Sam joined Johnson Matthey in 2015 as a research chemist in catalysis.


Tommaso Angelini completed his PhD in Chemical Science in 2010 from University of Perugia, Italy, working on the development of environmentally friendly synthetic protocols. During his postdoctoral studies, he finalised his work designing new continuous flow devices for the use of solid supported catalyst in low E-Factor transformations. Later, he gained experience in developing active pharmaceutical ingredient (API) production process at Procos (Italy). In 2015, he joined Johnson Matthey as Research Chemist, designing new enantioselective synthetic process for the preparation of APIs. He is now a Research Expert at Evotec Verona (Italy), working on the production of preclinical and Phase 1 API candidates.


Ahir Pushpanath obtained his PhD in Birkbeck College (University of London, UK) working on the engineering of enzymes for industrial biofuel production. With a biochemistry background, he specialises in the use of bioinformatics and computational biology in the rational design of new enzyme variants. Ahir joined Johnson Matthey in 2013 as a Senior Biologist and was instrumental in demonstrating the utility of computational techniques for rapid enzyme discovery through genome mining, in silico design and targeted enzyme engineering. He currently leads the enzyme development arm of biocatalysis, continuing to develop faster, more effective methods for ‘predictive biocatalysis’.


Amin Bornadel studied chemical engineering and received a PhD in biotechnology from Lund University in Sweden. For postdoctoral work, Amin went to Germany, where he carried out research within biocatalysis at University of Dresden and Technical University of Hamburg. In 2016, Amin joined Johnson Matthey to work as a biocatalysis researcher. He is currently a senior scientist working in the Biotech team.


Elina Siirola completed her PhD in 2012 from the University of Graz, Austria, where she worked on biocatalytic C=C bond hydrolysis. After a postdoctoral position in enzyme engineering at the Max Planck Institute for Coal Research, Germany, she joined Johnson Matthey in 2013, where she worked on biocatalysis research and development (R&D). Since 2017 she is a Principal Scientist in the Bioreactions group at Novartis Pharma in Basel, Switzerland.


Serena Bisagni completed her MSc in Industrial Biotechnology from the University of Pavia, Italy, in 2010 and then moved to Lund University, Sweden, for her postgraduate studies. In 2014 she obtained her PhD in Biotechnology in which she focused on the identification of new Baeyer-Villiger monooxygenases for fine chemicals synthesis within the Marie Curie Innovative Training Networks (ITN) ‘Biotrains’. In 2015 Serena joined Johnson Matthey. Her main interests are enzyme screening for synthesis of active pharmaceutical ingredients and fine chemicals and identification of novel biocatalysts.


Antonio Zanotti-Gerosa studied in Milano, Italy, completing his PhD in 1994 (organometallic chemistry). His academic experience include secondments to Imperial College, UK (Professor S. V. Ley), Nagoya University, Japan (Professor R. Noyori) and postdoctoral research at the University of Lausanne, Switzerland (Professor C. Floriani). Since 1997 he has been working on industrial applications of homogeneous catalysis. In 2003 he joined Johnson Matthey and, as R&D Director, he is leading the chemocatalysis group in the Cambridge laboratories.


Beatriz Domínguez gained her PhD in Synthetic Organic Chemistry from the University of Vigo, Spain, and then moved to the UK where she worked with Professor Tom Brown at the University of Southampton, UK, and with Professor Guy Lloyd-Jones at the University of Bristol, UK. In 2002 she joined Synetix, soon to become Johnson Matthey Catalysts and Chiral Technologies and has worked at Johnson Matthey’s facilities in Cambridge since. Beatriz has gained broad experience in the application of metal catalysis and biocatalysis, working closely with fine chemicals companies to deliver optimal catalysts for chemical processes.

By |2020-10-13T09:34:13+00:00October 13th, 2020|Weld Engineering Services|Comments Off on Biocatalytic Reduction of Activated Cinnamic Acid Derivatives

Academy Fellows receive Queen’s Birthday Honours

Congratulations to all our Fellows and friends who have been recognised in The Queen’s Birthday Honours list:

Order of the British Empire – Dame Commander of the Order of the British Empire (DBE)

Professor Dame Muffy Calder DBE OBE FREng FRSE, Vice Principal and head, College of Science and Engineering, University of Glasgow. For services to Research and Education

Order of the British Empire – Commanders of the Order of the British Empire – CBE

Jane Atkinson CBE FREng. Executive director, Engineering and Automation, Bilfinger UK. For services to Chemical Engineering

Order of the British Empire – Officer of the Order of the British Empire – OBE

Professor Simon Pollard OBE FREng. Pro Vice-Chancellor, Cranfield University. For services to Environmental Risk Management (Milton Keynes, Bedfordshire)

Professor Nilay Shah OBE FREng. Professor of Chemical Engineering, Imperial College London. For services to the Decarbonisation of the UK Economy

Honours for service to the fight against COVID-19

The Academy welcomes the recognition of all those who have worked to tackle the pandemic, from the engineers who have kept vital infrastructure and services running to medical engineers and innovators who have developed new technologies to assist medical teams, as acknowledged in our President’s Special Awards for Pandemic Service, announced in August.

We welcome in particular honours to the following:

Professor Catherine Noakes OBE, Professor of Environmental Engineering for Buildings, University of Leeds. For services to the Covid-19 response

The PerSo team in Southampton who developed personal respirators for healthcare workers:

Professor Paul Elkington MBE, Professor of Respiratory Medicine, Southampton University. For services to Medicine particularly during Covid-19 (Winchester, Hampshire)

Professor Hywel Morgan MBE, Professor of Bioelectronics, University of Southampton. For services to Biomedical Engineering particularly during Covid-19 (Salisbury, Wiltshire)

Also:

Professor Tim Baker MBE, Engineer, University College London. For services to Healthcare in the UK and Abroad during Covid-19. One of the UCL team who developed a CPAP breathing aid

Christopher Spicer BEM, Project Leader, Zephyr Plus Ventilator Design and Build, Babcock International.  For services to the Covid-19 response.

Ends

Notes for Editors

The Royal Academy of Engineering is harnessing the power of engineering to build a sustainable society and an inclusive economy that works for everyone.

In collaboration with our Fellows and partners, we’re growing talent and developing skills for the future, driving innovation and building global partnerships, and influencing policy and engaging the public.

Together we’re working to tackle the greatest challenges of our age.

For more information please contact: Pippa Cox at the Royal Academy of Engineering Tel. 020 7766 0745; email: Pippa.Cox@raeng.org.uk

By |2020-10-12T12:40:30+00:00October 12th, 2020|Engineering News|Comments Off on Academy Fellows receive Queen’s Birthday Honours

“Nanomaterials and Environmental Biotechnology”

Johnson Matthey Technol. Rev., 2020, 64, (4), 526

Introduction

This book is a fascinating account of how nanoparticles and nanotechnology are increasingly employed in a diverse array of applications ranging from plant growth to food packaging, biosensing, enzyme immobilisation and more. The book is divided into 20 chapters, each dealing with a specific application of nanotechnology and written by a different group of eminent academics from Indian universities and research institutes.

Each chapter is a review of its own topic area and the literature citations at the end of each chapter make it easy for the reader to use this book as a reference volume from which further in-depth reading can be pursued by following the cited literature.

Safety of Nanoparticles in Plants and Packaging

Chapter 1 deals with the phytotoxicity of nanoparticles in plants which can lead to both positive and negative outcomes. For example, improvement in germination rate and growth have been reported in seeds of rice exposed to carbon nanotubes; on the other hand, toxicity has also been widely reported, including studies on aluminium oxide and zinc oxide nanoparticles hindering root growth rate.

Chapter 2 considers an entirely separate but equally important area of use of nanomaterials in food packaging. It concludes that “it is essential to perform safety assessment of nanomaterials before their application in food packaging or processing” and provide a citation on how to do this using a “decision tree”.

Biosensors from Nanobiotechnology

Chapter 7 introduces how biosensors derived from nanobiotechnology can be used to monitor the environment and gain information relating to its health and the detrimental effects that modernisation and industrialisation have had on the planet. Biosensors need to be specific, rapid, sensitive and cost-effective. The advent of nanotechnology and biosensors has made this possible and the authors of this chapter (Gupta and Kakkar) explore the different types of biosensors that have been developed over recent years. The authors give a brief explanation of how different types of sensors work using a combination of bio-recognition components and different transduction principles. Types include: (a) immunosensors; (b) enzymatic biosensors; (c) whole-cell based sensors; (d) biosensors; (e) genosensors; (f) aptasensors and (g) biomimetic biosensors. The role of the transducer is to convert the biochemical response into an analysable and measurable signal. The outputs can be electrochemical, optical, piezoelectric, thermometric or magnetic.

Enzyme Immobilisation

Chapter 10 tackles the interesting area of enzyme immobilisation and the use of chitosan nanoparticles therein. The biopolymer’s distinct physicochemical properties have been described to offer an excellent microenvironment for enzyme immobilisation through adsorption, covalent binding or cross-linking, to achieve desirable enzymatic activity and stability. On the other hand, nanoparticles as materials of enhanced properties, owing to their high surface to volume ratio, have been introduced as attractive candidates for enzyme immobilisation. The chapter briefly discussed various methods for the preparation of chitosan nanoparticles for enzyme immobilisation including reverse micelle, coprecipitation, ionotropic gelation and ionic or emulsion cross-linking methods. Different methods for enzyme immobilisation such as support binding, cross-linking and entrapment, as well as different materials used as supports have been explained too. This section is then closed by presenting some examples for immobilisation of different enzyme families (for example, α-amylase, β-galactosidase, cellulase, laccase, lipase or protease) through applying chitosan nanoparticles.

Solid Lipid Nanoparticles

Chapter 13 offers an overview of solid lipid nanoparticles (SLN) as pharmaceuticals delivery systems whereas Chapter 19 gives a review of the most commonly used nanocarriers for drug delivery systems, with a focus on vesicular, polymeric and inorganic carriers.

SLN are lipid-based formulations, containing typically non-toxic biodegradable polymers forming a solid hydrophobic core suspended in an aqueous phase, the whole structure being stabilised by surfactants. The therapeutic agent is dissolved or dispersed in the solid lipid core, the SLN being suitable for incorporation and delivery of both hydrophilic and hydrophobic drugs. SLN present significant advantages over conventional drug delivery systems, including but not limited to biocompatibility and bioavailability, reduced drug leakage and increased physical stability of the drugs. In addition, they have been used successfully in various drug delivery techniques.

Novel applications of SLN as drug carriers are described in the field of gene therapy, peptide drug delivery and vaccines. SLN production methods use low mechanical force, allowing successful incorporation and delivery of nucleic acids in gene therapy. Overall, SLN are promising alternatives to traditional drug delivery systems, offering multiple advantages in terms of drug delivery and bioavailability, as well as being economically efficient and easy to produce on scale.

FDA-Approved Nanomedicines

An extensive summary of FDA-approved nanomedicines is included in Table 19.1 (Chapter 19), which also summarises the advantages of these specific formulations. The main types of nanocarriers described in Chapter 19 are vesicular carriers (liposomes and niosomes), polymeric nanoparticles and inorganic carriers (silica, gold and calcium nanoparticles). Liposomes and solid lipid nanoparticles (see also Chapter 13) are suitable for the delivery of drugs by any route, either oral or parenteral and can be used with both hydrophilic and lipophilic drugs. Their main advantages reside in protecting labile drugs, limited toxicity and a sustainable targeted release of the drug.

Inorganic nanocarriers exhibit higher stability and resistance to microbial growth, while having a low toxicity and allowing facile surface modifications. Mesoporous silica nanoparticles allow encapsulation of the therapeutic agent and targeted delivery to tumour cells in cancer therapy. Gold nanoparticles are biocompatible and bio-inert and have been successfully used in covalent conjugation with protein antigens in developing vaccines for cancer immunotherapy. Calcium phosphate nanoparticles are excellent candidates for developing ceramic-based carriers for peptide drugs prone to degradation, such as insulin.

Summary

In conclusion, I consider this book to be a positive contribution to the biotechnology literature, although I do not recommend reading this book sequentially from Page 1 as the variety of topics introduced is too great and each individual topic is not explored in depth. It is best used (and deserves recommendation) as a reference source from which each chapter can be used as the starting point to a more in-depth study or review of a particular topic. There are some negative aspects of the presentation of this work which do, unfortunately, detract from its enjoyment. These are exemplified in the poor quality of the diagrams, the grammatical errors and the somewhat odd references of Chapter 7.

Overall, though, this book is a positive addition to the biotechnology reference bookshelf.

“Nanomaterials and Environmental Biotechnology”

“Nanomaterials and Environmental Biotechnology”

By |2020-10-12T12:19:17+00:00October 12th, 2020|Weld Engineering Services|Comments Off on “Nanomaterials and Environmental Biotechnology”
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